SLC44A1

Solute carrier family 44 (choline transporter), member 1
Identifiers
Symbols	SLC44A1 ; CD92; CDW92; CHTL1; CTL1
External IDs	OMIM: 606105 MGI: 2140592 HomoloGene: 11137 GeneCards: SLC44A1 Gene
Gene ontology Molecular function • choline transmembrane transporter activity Cellular component • mitochondrial outer membrane • plasma membrane • membrane • integral component of membrane • extracellular exosome Biological process • phospholipid metabolic process • phosphatidylcholine biosynthetic process • choline transport • small molecule metabolic process • glycerophospholipid biosynthetic process • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23446	100434
Ensembl	ENSG00000070214	ENSMUSG00000028412
UniProt	Q8WWI5	Q6X893
RefSeq (mRNA)	NM_001286730	NM_001159633
RefSeq (protein)	NP_001273659	NP_001153105
Location (UCSC)	Chr 9: 105.24 – 105.44 Mb	Chr 4: 53.44 – 53.62 Mb
PubMed search

Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene.^[1][2][3]

See also

• Cluster of differentiation
• Solute carrier family

References

1. Wille S, Szekeres A, Majdic O, Prager E, Staffler G, Stockl J, Kunthalert D, Prieschl EE, Baumruker T, Burtscher H, Zlabinger GJ, Knapp W, Stockinger H (Nov 2001). "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells". J Immunol 167 (10): 5795–804. doi:10.4049/jimmunol.167.10.5795. PMID 11698453.
2. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A 97 (4): 1835–40. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
3. "Entrez Gene: SLC44A1 solute carrier family 44, member 1".

Further reading

• Yuan Z, Tie A, Tarnopolsky M, Bakovic M (2007). "Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1". Physiol. Genomics 26 (1): 76–90. doi:10.1152/physiolgenomics.00107.2005. PMID 16609143.
• Fullerton MD, Wagner L, Yuan Z, Bakovic M (2006). "Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages". Am. J. Physiol., Cell Physiol. 290 (4): C1230–8. doi:10.1152/ajpcell.00255.2005. PMID 16319125.
• Li D, Wang F, Lai M, et al. (2005). "A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C". J. Neurosci. 25 (8): 1914–23. doi:10.1523/JNEUROSCI.4790-04.2005. PMID 15728831.
• Traiffort E, Ruat M, O'Regan S, Meunier FM (2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J. Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662.
• Lecomte MJ, De Gois S, Guerci A, et al. (2005). "Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia". Mol. Cell. Neurosci. 28 (2): 303–13. doi:10.1016/j.mcn.2004.09.014. PMID 15691711.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Flajolet M, Rakhilin S, Wang H, et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMC 307683. PMID 14663150.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takekawa M, Maeda T, Saito H (1998). "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways". EMBO J. 17 (16): 4744–52. doi:10.1093/emboj/17.16.4744. PMC 1170803. PMID 9707433.

External links

• SLC44A1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)