SLC10A2

Solute carrier family 10 (sodium/bile acid cotransporter), member 2

Identifiers

SLC10A2 ; ASBT; IBAT; ISBT; NTCP2; PBAM

External IDs

OMIM: 601295 MGI: 1201406 HomoloGene: 390 ChEMBL: 2778 GeneCards: SLC10A2 Gene

Gene ontology
Molecular function	• bile acid:sodium symporter activity
Cellular component	• plasma membrane • integral component of plasma membrane • microvillus • apical plasma membrane
Biological process	• transport • sodium ion transport • bile acid metabolic process • bile acid and bile salt transport • small molecule metabolic process • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 13:
103.04 – 103.07 Mb

Chr 8:
5.09 – 5.11 Mb

PubMed search

The SLC10A2 (solute carrier family 10 member 2) gene in humans encodes the bile acid:sodium symporter known as the Apical sodium-bile acid transporter (ASBT) or as the ileal bile acid transporter (IBAT).^[1]^[2]

ASBT/IBAT is most highly expressed in the ileum where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.^[3]

The drug elobixibat is an inhibitor of ASBT/IBAT and is under development for the treatment of constipation and irritable bowel syndrome.^[4]

References

↑ Wong MH, Rao PN, Pettenati MJ, Dawson PA (Sep 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics 33 (3): 538–40. doi:10.1006/geno.1996.0233. PMID 8661017.
↑ "Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2".
↑ Dawson PA (2011). "Role of the intestinal bile acid transporters in bile acid and drug disposition". Handb Exp Pharmacol (201): 169–203. doi:10.1007/978-3-642-14541-4_4. PMC 3249407. PMID 21103970.
↑ Acosta A, Camilleri M (2014). "Elobixibat and its potential role in chronic idiopathic constipation". Therap Adv Gastroenterol 7 (4): 167–75. doi:10.1177/1756283X14528269. PMC 4107709. PMID 25057297.

Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology.". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407–17. doi:10.1097/00005176-200104000-00002. PMID 11396803.
Balakrishnan A, Polli JE (2006). "Apical Sodium Dependent Bile Acid Transporter (ASBT, SLC10A2): A Potential Prodrug Target". Mol. Pharm. 3 (3): 223–30. doi:10.1021/mp060022d. PMC 2796132. PMID 16749855.
Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity". J. Biol. Chem. 270 (45): 27228–34. doi:10.1074/jbc.270.45.27228. PMID 7592981.
Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)". J. Clin. Invest. 99 (8): 1880–7. doi:10.1172/JCI119355. PMC 508012. PMID 9109432.
Craddock AL, Love MW, Daniel RW, et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter". Am. J. Physiol. 274 (1 Pt 1): G157–69. PMID 9458785.
Montagnani M, Love MW, Rössel P, et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption". Scand. J. Gastroenterol. 36 (10): 1077–80. doi:10.1080/003655201750422693. PMID 11589382.
Love MW, Craddock AL, Angelin B, et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039–45. doi:10.1161/hq1201.100262. PMID 11742882.
Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha". J. Biol. Chem. 277 (34): 30559–66. doi:10.1074/jbc.M203511200. PMID 12055195.
Zelcer N, Saeki T, Bot I, et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMC 1223054. PMID 12220224.
Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter". Hepatology 40 (1): 149–56. doi:10.1002/hep.20295. PMID 15239098.
Xia X, Roundtree M, Merikhi A, et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes". J. Biol. Chem. 279 (43): 44931–7. doi:10.1074/jbc.M400969200. PMID 15304498.
Zhang EY, Phelps MA, Banerjee A, et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry 43 (36): 11380–92. doi:10.1021/bi049270a. PMID 15350125.
Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry 44 (24): 8908–17. doi:10.1021/bi050553s. PMID 15952798.
Nakahara M, Furuya N, Takagaki K, et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine". J. Biol. Chem. 280 (51): 42283–9. doi:10.1074/jbc.M507454200. PMID 16230354.
Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
Banerjee A, Swaan PW (2006). "Membrane Topology Of Human ASBT (SLC10A2) Determined By Dual Label Epitope Insertion Scanning Mutagenesis. New Evidence For Seven Transmembrane Domains". Biochemistry 45 (3): 943–53. doi:10.1021/bi052202j. PMC 2525805. PMID 16411770.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

(1):	high affinity glutamate and neutral amino-acid transporter SLC1A1 2 3 4 5 6 7

(2):	facilitative GLUT transporter SLC2A1 2 3 4 5 6 7 8 9 10 11 12 13 14

(3):	heavy subunits of heterodimeric amino-acid transporters SLC3A1 2

(4):	bicarbonate transporter SLC4A1 2 3 4 5 6 7 8 9 10 11

(5):	sodium glucose cotransporter SLC5A1 2 3 4 5 6 7 8 9 10 11 12

(6):	sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A16 SLC6A17 SLC6A18 SLC6A19 SLC6A20

(7):	cationic amino-acid transporter/glycoprotein-associated SLC7A1 SLC7A2 SLC7A3 SLC7A4 glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC7A10 SLC7A11 SLC7A13 SLC7A14

(8):	Na⁺/Ca²⁺ exchanger SLC8A1 SLC8A2 SLC8A3

(9):	Na⁺/H⁺ exchanger SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A10 SLC9A11

(10):	sodium bile salt cotransport SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 10A1 10A2 10A3 10A7

SLC11–20

(11):	proton coupled metal ion transporter SLC11A1 SLC11A2 11A3

(12):	electroneutral cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9

(13):	human Na⁺-sulfate/carboxylate cotransporter SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5

(14):	urea transporter SLC14A1 SLC14A2

(15):	proton oligopeptide cotransporter SLC15A1 SLC15A2 SLC15A3 SLC15A4

(16):	monocarboxylate transporter SLC16A1 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14

(17):	Vesicular glutamate transporter 1 SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9

(18):	vesicular monoamine transporter SLC18A1 SLC18A2 SLC18A3

(19):	folate/thiamine transporter SLC19A1 SLC19A2 SLC19A3

(20):	type III Na⁺-phosphate cotransporter SLC20A1 SLC20A2

SLC21–30

(21):	Organic anion-transporting polypeptide SLCO1A2 SLCO1B1 SLCO1B3 SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SLCO5A1(SLCO6A1)

(22):	organic cation/anion/zwitterion transporter SLC22A1 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A19 SLC22A20

(23):	Na+-dependent ascorbic acid transporter SLC23A1 SLC23A2 SLC23A3 SLC23A4

(24):	Na⁺/(Ca²⁺-K⁺) exchanger SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6

(25):	mitochondrial carrier SLC25A1 SLC25A2 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SLC25A7 SLC25A8 SLC25A9 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A18 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A27 SLC25A28 SLC25A29 SLC25A30 SLC25A31 SLC25A32 SLC25A33 SLC25A34 SLC25A35 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A40 SLC25A41 SLC25A42 SLC25A43 SLC25A44 SLC25A45 SLC25A46

(26):	multifunctional anion exchanger SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 SLC26A10 SLC26A11

(27):	fatty acid transport proteins SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6

(28):	Na⁺-coupled nucleoside transport (SLC28A1 SLC28A2 SLC28A3

(29):	facilitative nucleoside transporter SLC29A1 SLC29A2 SLC29A3 SLC29A4

(30):	zinc efflux SLC30A1 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC30A10

SLC31–40

(31):	copper transporter SLC31A1

(32):	Vesicular glutamate transporter 1 SLC32A1

(33):	Acetyl-CoA transporter SLC33A1

(34):	type II Na⁺-phosphate cotransporter SLC34A1 SLC34A2 SLC34A3

(35):	nucleoside-sugar transporter SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35E1 SLC35E2 SLC35E3 SLC35E4

(36):	proton-coupled amino-acid transporter SLC36A1 SLC36A2 SLC36A3 SLC36A436A2

(37):	sugar-phosphate/phosphate exchanger SLC37A1 SLC37A2 SLC37A3 SLC37A4

(38):	System A & N, sodium-coupled neutral amino-acid transporter SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A10

(39):	metal ion transporter SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14

(40):	basolateral iron transporter SLC40A1

SLC41–48

(41):	Magnesium transporter E SLC41A1 SLC41A2 SLC41A3

(42):	Ammonia transporter RhAG RhBG RhCG

(43):	Na⁺-independent, system-L like amino-acid transporter SLC43A1 SLC43A2 SLC43A3

(44):	Choline-like transporter SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5

(45):	Putative sugar transporter SLC45A1 SLC45A2 SLC54A3 SLC45A4

(46):	Folate transporter SLC46A1 SLC46A2

(47):	multidrug and toxin extrusion SLC47A1 SLC47A2

(48):	Heme transporter

SLCO1–4

O1A2 O1B1 O1B3 O2B1 O431 O4A1

Ion pumps

Symporter, Cotransporter	Na⁺/K⁺,Cl⁻ Na⁺/P_i3 Na⁺/Cl⁻ Na⁺/glucose Na⁺/I⁻ Cl⁻/K⁺ 4 5

Antiporter (exchanger)	Na⁺/H⁺ Na⁺/Ca²⁺ Na⁺/(Ca²⁺-K⁺) - Cl⁻/HCO− 3 (Band 3) Cl⁻-formate Cl⁻-oxalate

see also solute carrier disorders

This article is issued from Wikipedia - version of the Saturday, May 07, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

SLC10A2

See also

References

Further reading