SLC39A1

Solute carrier family 39 (zinc transporter), member 1
Identifiers
Symbols	SLC39A1 ; ZIP1; ZIRTL
External IDs	OMIM: 604740 MGI: 1353474 HomoloGene: 40906 GeneCards: SLC39A1 Gene
Gene ontology Molecular function • receptor binding • zinc ion transmembrane transporter activity • inorganic cation transmembrane transporter activity Cellular component • endoplasmic reticulum membrane • plasma membrane • membrane • integral component of membrane Biological process • in utero embryonic development • cation transport • embryonic cranial skeleton morphogenesis • transmembrane transport • limb development • zinc II ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27173	30791
Ensembl	ENSG00000143570	ENSMUSG00000052310
UniProt	Q9NY26	Q9QZ03
RefSeq (mRNA)	NM_001271957	NM_013901
RefSeq (protein)	NP_001258886	NP_038929
Location (UCSC)	Chr 1: 153.96 – 153.97 Mb	Chr 3: 90.25 – 90.25 Mb
PubMed search

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.^{[1] [2][3]}

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.^[4]

See also

• Solute carrier family

References

1. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
2. Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
3. "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
4. Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
• Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells.". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMID 12888280.
• Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
• Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580.