Sodium–hydrogen antiporter

The sodium–hydrogen antiporter or sodium–hydrogen exchanger is a membrane protein found in many cells, and especially in those of the nephron of the kidney. Specifically in the intercalary cells of the collecting duct and in the epithelial cells of the proximal convoluted tubule. The membrane pump is primarily responsible for maintaining the balance of pH.^[1] Angiotensin II upregulates this antiporter in the proximal convoluted tubule in order to promote Na⁺ reabsorption and H⁺ secretion.

Isoforms

There are several isoforms of the antiporter:

• Sodium–hydrogen antiporter 1
• Sodium–hydrogen antiporter 2
• Sodium–hydrogen antiporter 3
• Sodium–hydrogen antiporter 5
• Sodium–hydrogen antiporter 6
• Sodium–hydrogen antiporter 8

References

External links

• Sodium-Hydrogen Exchanger at the US National Library of Medicine Medical Subject Headings (MeSH)