SLC38A2

Solute carrier family 38, member 2
Identifiers
Symbols	SLC38A2 ; ATA2; PRO1068; SAT2; SNAT2
External IDs	OMIM: 605180 MGI: 1915010 HomoloGene: 23132 IUPHAR: 1170 GeneCards: SLC38A2 Gene
Gene ontology Molecular function • protein binding • amino acid transmembrane transporter activity • symporter activity Cellular component • plasma membrane • integral component of plasma membrane Biological process • amino acid transmembrane transport • ion transport • sodium ion transport • amino acid transport • synaptic transmission • neurotransmitter secretion • glutamate secretion • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54407	67760
Ensembl	ENSG00000134294	ENSMUSG00000022462
UniProt	Q96QD8	Q8CFE6
RefSeq (mRNA)	NM_001307936	NM_175121
RefSeq (protein)	NP_001294865	NP_780330
Location (UCSC)	Chr 12: 46.36 – 46.37 Mb	Chr 15: 96.69 – 96.7 Mb
PubMed search

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.^[1][2][3]

See also

• Solute carrier family

References

1. Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem 275 (22): 16473–7. doi:10.1074/jbc.C000205200. PMID 10747860.
2. Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J 92 (7): 2621–32. doi:10.1529/biophysj.106.100776. PMC 1864845. PMID 17237199.
3. "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Hatanaka T, Huang W, Wang H, et al. (2000). "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.". Biochim. Biophys. Acta 1467 (1): 1–6. doi:10.1016/S0005-2736(00)00252-2. PMID 10930503.
• Freeman TL, Thiele GM, Tuma DJ, et al. (2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane.". Arch. Biochem. Biophys. 400 (2): 215–22. doi:10.1016/S0003-9861(02)00006-1. PMID 12054432.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Palii SS, Chen H, Kilberg MS (2004). "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.". J. Biol. Chem. 279 (5): 3463–71. doi:10.1074/jbc.M310483200. PMID 14623874.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Franchi-Gazzola R, Gaccioli F, Bevilacqua E, et al. (2005). "The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity.". Biochim. Biophys. Acta 1667 (2): 157–66. doi:10.1016/j.bbamem.2004.09.012. PMID 15581851.
• Bevilacqua E, Bussolati O, Dall'Asta V, et al. (2005). "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.". FEBS Lett. 579 (16): 3376–80. doi:10.1016/j.febslet.2005.05.002. PMID 15922329.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Novak D, Quiggle F, Haafiz A (2006). "Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells.". Biochimie 88 (1): 39–44. doi:10.1016/j.biochi.2005.07.002. PMID 16125834.
• Palii SS, Thiaville MM, Pan YX, et al. (2006). "Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene.". Biochem. J. 395 (3): 517–27. doi:10.1042/BJ20051867. PMC 1462688. PMID 16445384.
• Melone M, Varoqui H, Erickson JD, Conti F (2006). "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex.". Neuroscience 140 (1): 281–92. doi:10.1016/j.neuroscience.2006.02.042. PMID 16616430.
• Gaccioli F, Huang CC, Wang C, et al. (2006). "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.". J. Biol. Chem. 281 (26): 17929–40. doi:10.1074/jbc.M600341200. PMID 16621798.
• Jones HN, Ashworth CJ, Page KR, McArdle HJ (2006). "Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).". Am. J. Physiol. Endocrinol. Metab. 291 (3): E596–603. doi:10.1152/ajpendo.00359.2005. PMID 16621896.