SLC11A1

Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1

Identifiers

SLC11A1 ; LSH; NRAMP; NRAMP1

External IDs

OMIM: 600266 MGI: 1345275 HomoloGene: 73884 GeneCards: SLC11A1 Gene

Gene ontology
Molecular function	• manganese ion transmembrane transporter activity • protein homodimerization activity • transition metal ion transmembrane transporter activity • metal ion:proton antiporter activity
Cellular component	• lysosome • late endosome • plasma membrane • integral component of plasma membrane • cell outer membrane • phagocytic vesicle membrane • late endosome membrane • tertiary granule membrane
Biological process	• protein import into nucleus, translocation • negative regulation of cytokine production • positive regulation of cytokine production • T cell proliferation involved in immune response • T cell cytokine production • positive regulation of dendritic cell antigen processing and presentation • positive regulation of T-helper 1 type immune response • iron ion transport • manganese ion transport • cellular cadmium ion homeostasis • cellular iron ion homeostasis • phagocytosis • inflammatory response • vacuolar acidification • response to bacterium • positive regulation of gene expression • nitrite transport • activation of protein kinase activity • response to lipopolysaccharide • interleukin-2 production • interleukin-3 production • positive regulation of interferon-gamma production • response to interferon-gamma • wound healing • macrophage activation • defense response to bacterium • defense response to protozoan • L-arginine import • MHC class II biosynthetic process • respiratory burst • positive regulation of transcription from RNA polymerase II promoter • antigen processing and presentation of peptide antigen • mRNA stabilization • positive regulation of phagocytosis • defense response to Gram-negative bacterium • interaction with host • iron ion homeostasis • transmembrane transport • multicellular organismal iron ion homeostasis • cadmium ion transmembrane transport • divalent metal ion export • manganese ion transmembrane transport • phagosome maturation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
218.38 – 218.4 Mb

Chr 1:
74.38 – 74.39 Mb

PubMed search

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.^[1]^[2]^[3]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.^[4] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.^[3]

References

↑ Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P (Dec 1994). "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". J Exp Med 180 (5): 1741–52. doi:10.1084/jem.180.5.1741. PMC 2191750. PMID 7964458.
↑ Kishi F (Dec 1994). "Isolation and characterization of human Nramp cDNA". Biochem. Biophys. Res. Commun. 204 (3): 1074–80. doi:10.1006/bbrc.1994.2572. PMID 7980580.
1 2 "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1".
↑ Teras, IuKh.; Ryĭgas, EM.; Kazakova, II.; Ranne, KhP.; Trapido, LE. (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases].". Ter Arkh 52 (3): 123–5. PMID 7385031.

Blackwell JM, Searle S, Mohamed H, White JK (2003). "Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.". Immunol. Lett. 85 (2): 197–203. doi:10.1016/S0165-2478(02)00231-6. PMID 12527228.
Awomoyi AA (2007). "The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer?". FEMS Immunol. Med. Microbiol. 49 (3): 324–9. doi:10.1111/j.1574-695X.2007.00231.x. PMC 1890654. PMID 17378896.
Liu J, Fujiwara TM, Buu NT, et al. (1995). "Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.". Am. J. Hum. Genet. 56 (4): 845–53. PMC 1801220. PMID 7717395.
Vidal SM, Malo D, Vogan K, et al. (1993). "Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg.". Cell 73 (3): 469–85. doi:10.1016/0092-8674(93)90135-D. PMID 8490962.
Blackwell JM, Barton CH, White JK, et al. (1996). "Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism.". Mol. Med. 1 (2): 194–205. PMC 2229945. PMID 8529098.
Kishi F, Nobumoto M (1996). "Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes.". Immunol. Lett. 47 (1-2): 93–6. doi:10.1016/0165-2478(95)00070-L. PMID 8537108.
Gruenheid S, Pinner E, Desjardins M, Gros P (1997). "Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome.". J. Exp. Med. 185 (4): 717–30. doi:10.1084/jem.185.4.717. PMC 2196151. PMID 9034150.
Atkinson PG, Blackwell JM, Barton CH (1997). "Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages.". Biochem. J. 325. ( Pt 3): 779–86. PMC 1218623. PMID 9271100.
Gruenheid S, Canonne-Hergaux F, Gauthier S, et al. (1999). "The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes.". J. Exp. Med. 189 (5): 831–41. doi:10.1084/jem.189.5.831. PMC 2192949. PMID 10049947.
Searle S, Blackwell JM (1999). "Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility.". J. Med. Genet. 36 (4): 295–9. doi:10.1136/jmg.36.4.295. PMC 1734346. PMID 10227396.
Marquet S, Lepage P, Hudson TJ, et al. (2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35.". Mamm. Genome 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134.
Canonne-Hergaux F, Calafat J, Richer E, et al. (2002). "Expression and subcellular localization of NRAMP1 in human neutrophil granules.". Blood 100 (1): 268–75. doi:10.1182/blood.V100.1.268. PMID 12070036.
Rodríguez MR, González-Escribano MF, Aguilar F, et al. (2003). "Association of NRAMP1 promoter gene polymorphism with the susceptibility and radiological severity of rheumatoid arthritis.". Tissue Antigens 59 (4): 311–5. doi:10.1034/j.1399-0039.2002.590410.x. PMID 12135431.
Bassuny WM, Ihara K, Matsuura N, et al. (2002). "Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes.". Immunogenetics 54 (4): 282–5. doi:10.1007/s00251-002-0459-3. PMID 12136340.
Søborg C, Andersen AB, Madsen HO, et al. (2002). "Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis.". J. Infect. Dis. 186 (4): 517–21. doi:10.1086/341775. PMID 12195379.
Puzyrev VP, Freĭdin MB, Rudko AA, et al. (2002). "[Polymorphisms of the candidate genes for genetic susceptibility to tuberculosis in the Slavic population of Siberia: a pilot study]". Mol. Biol. (Mosk.) 36 (5): 788–91. PMID 12391841.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

(1):	high affinity glutamate and neutral amino-acid transporter SLC1A1 2 3 4 5 6 7

(2):	facilitative GLUT transporter SLC2A1 2 3 4 5 6 7 8 9 10 11 12 13 14

(3):	heavy subunits of heterodimeric amino-acid transporters SLC3A1 2

(4):	bicarbonate transporter SLC4A1 2 3 4 5 6 7 8 9 10 11

(5):	sodium glucose cotransporter SLC5A1 2 3 4 5 6 7 8 9 10 11 12

(6):	sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A16 SLC6A17 SLC6A18 SLC6A19 SLC6A20

(7):	cationic amino-acid transporter/glycoprotein-associated SLC7A1 SLC7A2 SLC7A3 SLC7A4 glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC7A10 SLC7A11 SLC7A13 SLC7A14

(8):	Na+/Ca2+ exchanger SLC8A1 SLC8A2 SLC8A3

(9):	Na+/H+ exchanger SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A10 SLC9A11

(10):	sodium bile salt cotransport SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 10A1 10A2 10A3 10A7

SLC11–20

(11):	proton coupled metal ion transporter SLC11A1 SLC11A2 11A3

(12):	electroneutral cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9

(13):	human Na+-sulfate/carboxylate cotransporter SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5

(14):	urea transporter SLC14A1 SLC14A2

(15):	proton oligopeptide cotransporter SLC15A1 SLC15A2 SLC15A3 SLC15A4

(16):	monocarboxylate transporter SLC16A1 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14

(17):	Vesicular glutamate transporter 1 SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9

(18):	vesicular monoamine transporter SLC18A1 SLC18A2 SLC18A3

(19):	folate/thiamine transporter SLC19A1 SLC19A2 SLC19A3

(20):	type III Na+-phosphate cotransporter SLC20A1 SLC20A2

SLC21–30

(21):	Organic anion-transporting polypeptide SLCO1A2 SLCO1B1 SLCO1B3 SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SLCO5A1(SLCO6A1)

(22):	organic cation/anion/zwitterion transporter SLC22A1 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A19 SLC22A20

(23):	Na+-dependent ascorbic acid transporter SLC23A1 SLC23A2 SLC23A3 SLC23A4

(24):	Na+/(Ca2+-K+) exchanger SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6

(25):	mitochondrial carrier SLC25A1 SLC25A2 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SLC25A7 SLC25A8 SLC25A9 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A18 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A27 SLC25A28 SLC25A29 SLC25A30 SLC25A31 SLC25A32 SLC25A33 SLC25A34 SLC25A35 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A40 SLC25A41 SLC25A42 SLC25A43 SLC25A44 SLC25A45 SLC25A46

(26):	multifunctional anion exchanger SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 SLC26A10 SLC26A11

(27):	fatty acid transport proteins SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6

(28):	Na+-coupled nucleoside transport (SLC28A1 SLC28A2 SLC28A3

(29):	facilitative nucleoside transporter SLC29A1 SLC29A2 SLC29A3 SLC29A4

(30):	zinc efflux SLC30A1 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC30A10

SLC31–40

(31):	copper transporter SLC31A1

(32):	Vesicular glutamate transporter 1 SLC32A1

(33):	Acetyl-CoA transporter SLC33A1

(34):	type II Na+-phosphate cotransporter SLC34A1 SLC34A2 SLC34A3

(35):	nucleoside-sugar transporter SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35E1 SLC35E2 SLC35E3 SLC35E4

(36):	proton-coupled amino-acid transporter SLC36A1 SLC36A2 SLC36A3 SLC36A436A2

(37):	sugar-phosphate/phosphate exchanger SLC37A1 SLC37A2 SLC37A3 SLC37A4

(38):	System A & N, sodium-coupled neutral amino-acid transporter SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A10

(39):	metal ion transporter SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14

(40):	basolateral iron transporter SLC40A1

SLC41–48

(41):	Magnesium transporter E SLC41A1 SLC41A2 SLC41A3

(42):	Ammonia transporter RhAG RhBG RhCG

(43):	Na+-independent, system-L like amino-acid transporter SLC43A1 SLC43A2 SLC43A3

(44):	Choline-like transporter SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5

(45):	Putative sugar transporter SLC45A1 SLC45A2 SLC54A3 SLC45A4

(46):	Folate transporter SLC46A1 SLC46A2

(47):	multidrug and toxin extrusion SLC47A1 SLC47A2

(48):	Heme transporter

SLCO1–4

O1A2 O1B1 O1B3 O2B1 O431 O4A1

Ion pumps

Symporter, Cotransporter	Na+/K+,l- Na/Pi3 Na+/Cl- Na/glucose Na+/I- Cl-/K+ 4 5

Antiporter (exchanger)	Na+/H+ Na+/Ca2+ Na+/(Ca2+-K+) - Cl-/HCO3- (Band 3) Cl-formate exchanger Cl-oxalate exchanger

see also solute carrier disorders

Metabolism: Metal metabolism

Transition metal

Iron metabolism

Absorption in
Duodenum

Iron(II) oxide:	DMT1 (SLC11A2) Ferritin Hephaestin/Ferroportin (SLC11A3/SLC40A1) Transferrin to Transferrin receptor TFR1 TFR2

Iron(III) oxide:	Duodenal cytochrome B Integrin Calreticulin/mobilferrin Ferritin

Other

Iron-binding proteins:	Ferritin

Hepcidin/HAMP Hemojuvelin Iron-responsive element-binding protein Aconitase Ceruloplasmin HFE Hemosiderin Lactoferrin

Copper metabolism

Zinc metabolism

Electrolyte

Sodium metabolism	Na+/K+-ATPase

Phosphate metabolism	Phosphoric acids and phosphates

Magnesium metabolism	Magnesium transporter

Calcium metabolism	Calcium-sensing receptor Calcium-binding protein

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SLC11A1

See also

References

Further reading