SLC12A7

Solute carrier family 12 (potassium/chloride transporter), member 7
Identifiers
Symbols	SLC12A7 ; KCC4
External IDs	OMIM: 604879 MGI: 1342283 HomoloGene: 21312 IUPHAR: 974 GeneCards: SLC12A7 Gene
Gene ontology Molecular function • potassium:chloride symporter activity • protein kinase binding • potassium ion symporter activity Cellular component • plasma membrane • integral component of plasma membrane Biological process • transport • ion transport • cell volume homeostasis • synaptic transmission • potassium ion import • chloride ion homeostasis • potassium ion homeostasis • transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10723	20499
Ensembl	ENSG00000113504	ENSMUSG00000017756
UniProt	Q9Y666	Q9WVL3
RefSeq (mRNA)	NM_006598	NM_011390
RefSeq (protein)	NP_006589	NP_035520
Location (UCSC)	Chr 5: 1.05 – 1.11 Mb	Chr 13: 73.76 – 73.82 Mb
PubMed search

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.^[1][2]

See also

• Solute carrier family
• cotransporter

References

1. Mount DB, Mercado A, Song L, Xu J, George AL Jr, Delpire E, Gamba G (Jul 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J Biol Chem 274 (23): 16355–62. doi:10.1074/jbc.274.23.16355. PMID 10347194.
2. "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".

Further reading

• Mercado A, Song L, Vazquez N, et al. (2000). "Functional comparison of the K⁺-Cl⁻ cotransporters KCC1 and KCC4". J. Biol. Chem. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Boettger T, Hübner CA, Maier H, et al. (2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature 416 (6883): 874–8. doi:10.1038/416874a. PMID 11976689.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
• Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hsu YM, Chou CY, Chen HH, et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". J. Cell. Physiol. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.