SLC26A8

Solute carrier family 26 (anion exchanger), member 8
Identifiers
Symbols	SLC26A8 ; SPGF3; TAT1
External IDs	OMIM: 608480 MGI: 2385046 HomoloGene: 27095 GeneCards: SLC26A8 Gene
Gene ontology Molecular function • chloride channel activity • protein binding • secondary active sulfate transmembrane transporter activity • sulfate transmembrane transporter activity • anion:anion antiporter activity • oxalate transmembrane transporter activity Cellular component • plasma membrane • integral component of membrane Biological process • anion transport • chloride transport • multicellular organismal development • sulfate transport • oxalate transport • sperm motility • sperm capacitation • meiotic cell cycle • sulfate transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116369	224661
Ensembl	ENSG00000112053	ENSMUSG00000036196
UniProt	Q96RN1	Q8R0C3
RefSeq (mRNA)	NM_001193476	NM_001290320
RefSeq (protein)	NP_001180405	NP_001277249
Location (UCSC)	Chr 6: 35.94 – 36.02 Mb	Chr 17: 28.64 – 28.69 Mb
PubMed search

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.^[1][2][3]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.^[3]

Interactions

SLC26A8 has been shown to interact with RACGAP1.^[4]

References

1. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
2. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
3. "Entrez Gene: SLC26A8 solute carrier family 26, member 8".
4. Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.

Further reading

• Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. PMID 11581495.
• Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655.
• Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
• Mocellin R, Bühlmeyer K (1975). "Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension". Eur J Cardiol 3 (3): 205–11. PMID 1183472.