IGLL1

Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene.^[1]^[2]^[3] IGLL1 has also recently been designated CD179B (cluster of differentiation 179B).

It is associated with agammaglobulinemia-2.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.^[3]

References

↑ Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558.
↑ Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029.
1 2 "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

Evans RJ, Hollis GF (1991). "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution". J. Exp. Med. 173 (2): 305–11. doi:10.1084/jem.173.2.305. PMC 2118775. PMID 1703205.
Bossy D, Milili M, Zucman J, et al. (1992). "Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells". Int. Immunol. 3 (11): 1081–90. doi:10.1093/intimm/3.11.1081. PMID 1760403.
Mattei MG, Fumoux F, Roeckel N, et al. (1991). "The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus". Genomics 9 (3): 544–6. doi:10.1016/0888-7543(91)90422-B. PMID 1903358.
Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface". J. Exp. Med. 172 (3): 973–6. doi:10.1084/jem.172.3.973. PMC 2188549. PMID 2117639.
Schiff C, Bensmana M, Guglielmi P, et al. (1991). "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene". Int. Immunol. 2 (3): 201–7. doi:10.1093/intimm/2.3.201. PMID 2128466.
Hollis GF, Evans RJ, Stafford-Hollis JM, et al. (1989). "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5552–6. doi:10.1073/pnas.86.14.5552. PMC 297661. PMID 2501791.
Chang H, Dmitrovsky E, Hieter PA, et al. (1986). "Identification of three new Ig lambda-like genes in man". J. Exp. Med. 163 (2): 425–35. doi:10.1084/jem.163.2.425. PMC 2188038. PMID 3003227.
Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J. Biol. Chem. 269 (45): 28347–53. PMID 7961773.
Bauer TR, McDermid HE, Budarf ML, et al. (1993). "Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2". Immunogenetics 38 (6): 387–99. doi:10.1007/BF00184519. PMID 8406611.
Sohi MK, Corper AL, Wan T, et al. (1996). "Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4". Immunology 88 (4): 636–41. doi:10.1046/j.1365-2567.1996.d01-692.x. PMC 1456622. PMID 8881769.
Donohoe ME, Blomberg BB (1997). "The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity". J. Immunol. 158 (4): 1681–91. PMID 9029104.
Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
Corper AL, Sohi MK, Bonagura VR, et al. (1997). "Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction". Nat. Struct. Biol. 4 (5): 374–81. doi:10.1038/nsb0597-374. PMID 9145108.
Minegishi Y, Coustan-Smith E, Wang YH, et al. (1998). "Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and Agammaglobulinemia". J. Exp. Med. 187 (1): 71–7. doi:10.1084/jem.187.1.71. PMC 2199185. PMID 9419212.
Miyazaki T, Kato I, Takeshita S, et al. (1999). "Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines". Int. Immunol. 11 (8): 1195–202. doi:10.1093/intimm/11.8.1195. PMID 10421777.
Donohoe ME, Beck-Engeser GB, Lonberg N, et al. (2000). "Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype". J. Immunol. 164 (10): 5269–76. doi:10.4049/jimmunol.164.10.5269. PMID 10799888.
Nomura K, Kanegane H, Karasuyama H, et al. (2000). "Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway". Blood 96 (2): 610–7. PMID 10887125.
Fang T, Smith BP, Roman CA (2001). "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression". J. Immunol. 167 (7): 3846–57. doi:10.4049/jimmunol.167.7.3846. PMID 11564802.

PDB gallery

2h32: Crystal structure of the pre-B cell receptor

2h3n: Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Antibodies

Antibodies	Light chain IGK@ IGL@ surrogate IGLL1 Heavy chain IGH@ IGHM IgA IgD IgE IgG IgM IgY Heavy-chain antibody/IgNAR

see also disorders of globin and globulin proteins

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IGLL1

References

Further reading