IGK@

Immunoglobulin kappa locus
Identifiers
Symbols	IGK ; IGK@
External IDs	GeneCards: IGK Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	50802	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).^[1]

In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.^[2] These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.

Genes

The immunoglobulin kappa locus contains the following genes:

• IGKC: immunoglobulin kappa constant
• IGKJ@: immunoglobulin kappa joining group
  • IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5
• IGKV@: immunoglobulin kappa variable group
  • IGKV1-5, IGKV1-6, IGKV1-8, IGKV1-9, IGKV1-12, IGKV1-16, IGKV1-17, IGKV1-27, IGKV1-33
  • IGKV1D-8, IGKV1D-12, IGKV1D-13, IGKV1D-16, IGKV1D-17, IGKV1D-22, IGKV1D-27, IGKV1D-32, IGKV1D-33, IGKV1D-39, IGKV1D-43
  • IGKV2-24, IGKV2-28, IGKV2-30, IGKV2-40
  • IGKV2D-26, IGKV2D-28, IGKV2D-29, IGKV2D-30, IGKV2D-40
  • IGKV3-11, IGKV3-15, IGKV3-20
  • IGKV3D-7, IGKV3D-11, IGKV3D-20
  • IGKV4-1
  • IGKV5-2
• and a number of non-functional and pseudogenes

References

1. Criscitiello MF, Flajnik MF (2007). "Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates". Eur. J. Immunol. 37 (10): 2683–94. doi:10.1002/eji.200737263. PMID 17899545.
2. Male, D., Brostoff, J., Roth, D.B., & Roitt, I. 2006. Immunology. 7th ed., Canada: Elsevier Limited

Further reading