Interleukin 20 receptor, beta subunit

Interleukin 20 receptor beta
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4DOH​
Identifiers
Symbols	IL20RB ; DIRS1; FNDC6; IL-20R2
External IDs	OMIM: 605621 HomoloGene: 86034 GeneCards: IL20RB Gene
Gene ontology Molecular function • cytokine receptor activity • interleukin-20 binding Cellular component • plasma membrane • integral component of membrane Biological process • negative regulation of type IV hypersensitivity • inflammatory response to antigenic stimulus • immune response-inhibiting signal transduction • cytokine-mediated signaling pathway • negative regulation of interferon-gamma production • negative regulation of interleukin-2 production • positive regulation of interleukin-10 production • positive regulation of interleukin-4 production • negative regulation of T cell proliferation • homeostasis of number of cells within a tissue Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53833	213208
Ensembl	ENSG00000174564	ENSMUSG00000044244
UniProt	Q6UXL0	E9Q9A6
RefSeq (mRNA)	NM_144717	NM_001033543
RefSeq (protein)	NP_653318	NP_001028715
Location (UCSC)	Chr 3: 136.95 – 137.01 Mb	Chr 9: 100.46 – 100.49 Mb
PubMed search

Interleukin-20 receptor beta chain is a protein that in humans is encoded by the IL20RB gene.^[1][2][3]

References

1. Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA (Feb 2001). "Interleukin 20: discovery, receptor identification, and role in epidermal function". Cell 104 (1): 9–19. doi:10.1016/S0092-8674(01)00187-8. PMID 11163236.
2. Wei CC, Hsu YH, Li HH, Wang YC, Hsieh MY, Chen WY, Hsing CH, Chang MS (Sep 2006). "IL-20: biological functions and clinical implications". J Biomed Sci 13 (5): 601–12. doi:10.1007/s11373-006-9087-5. PMID 16703417.
3. "Entrez Gene: IL20RB interleukin 20 receptor beta".

Further reading

• Dumoutier L, Leemans C, Lejeune D, et al. (2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.". J. Immunol. 167 (7): 3545–9. doi:10.4049/jimmunol.167.7.3545. PMID 11564763.
• Parrish-Novak J, Xu W, Brender T, et al. (2003). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.". J. Biol. Chem. 277 (49): 47517–23. doi:10.1074/jbc.M205114200. PMID 12351624.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Pletnev S, Magracheva E, Kozlov S, et al. (2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.". Biochemistry 42 (43): 12617–24. doi:10.1021/bi0354583. PMID 14580208.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.