IL1RAP

Interleukin 1 receptor accessory protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3O4O​, 4DEP​
Identifiers
Symbols	IL1RAP ; C3orf13; IL-1RAcP; IL1R3
External IDs	OMIM: 602626 MGI: 104975 HomoloGene: 1643 GeneCards: IL1RAP Gene
Gene ontology Molecular function • signal transducer activity • interleukin-1 receptor activity • interleukin-1 receptor binding Cellular component • extracellular region • cytoplasm • plasma membrane • integral component of plasma membrane • membrane • protein complex Biological process • protein complex assembly • inflammatory response • immune response • cytokine-mediated signaling pathway • interleukin-2 biosynthetic process • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3556	16180
Ensembl	ENSG00000196083	ENSMUSG00000022514
UniProt	Q9NPH3	Q61730
RefSeq (mRNA)	NM_001167928	NM_001159317
RefSeq (protein)	NP_001161400	NP_001152789
Location (UCSC)	Chr 3: 190.51 – 190.66 Mb	Chr 16: 26.58 – 26.73 Mb
PubMed search

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.^[1][2][3]

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.^[3]

Interactions

IL1RAP has been shown to interact with TOLLIP^[4] and Interleukin 1 receptor, type I.^[5]

References

1. Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509.
2. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
3. "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein".
4. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. (ENGLAND) 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325.
5. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

• Greenfeder SA, Nunes P, Kwee L, et al. (1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex". J. Biol. Chem. 270 (23): 13757–65. doi:10.1074/jbc.270.23.13757. PMID 7775431.
• Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
• Cullinan EB, Kwee L, Nunes P, et al. (1998). "IL-1 receptor accessory protein is an essential component of the IL-1 receptor". J. Immunol. 161 (10): 5614–20. PMID 9820540.
• Lang D, Knop J, Wesche H, et al. (1999). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". J. Immunol. 161 (12): 6871–7. PMID 9862719.
• Morton NM, de Groot RP, Cawthorne MA, Emilsson V (1999). "Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells". FEBS Lett. 442 (1): 57–60. doi:10.1016/S0014-5793(98)01623-8. PMID 9923604.
• Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. PMC 84278. PMID 10373529.
• Jensen LE, Muzio M, Mantovani A, Whitehead AS (2000). "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein". J. Immunol. 164 (10): 5277–86. doi:10.4049/jimmunol.164.10.5277. PMID 10799889.
• Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
• Bigonnesse F, Marois M, Maheux R, Akoum A (2001). "Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 7 (4): 333–9. doi:10.1093/molehr/7.4.333. PMID 11279295.
• Jefferies C, Bowie A, Brady G, et al. (2001). "Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1". Mol. Cell. Biol. 21 (14): 4544–52. doi:10.1128/MCB.21.14.4544-4552.2001. PMC 87113. PMID 11416133.
• Radons J, Gabler S, Wesche H, et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ruhul Amin AR, Machida K, Oshima K, et al. (2003). "A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling". Oncogene 21 (57): 8871–8. doi:10.1038/sj.onc.1206018. PMID 12483539.
• Smith DE, Hanna R, Della Friend; et al. (2003). "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action". Immunity 18 (1): 87–96. doi:10.1016/S1074-7613(02)00514-9. PMID 12530978.
• Boch JA, Yoshida Y, Koyama Y, et al. (2003). "Characterization of a cascade of protein interactions initiated at the IL-1 receptor". Biochem. Biophys. Res. Commun. 303 (2): 525–31. doi:10.1016/S0006-291X(03)00385-1. PMID 12659850.
• Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Jensen LE, Whitehead AS (2004). "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis". Cell. Signal. 15 (8): 793–802. doi:10.1016/S0898-6568(03)00039-1. PMID 12781872.