Testican

Testican is a type of proteoglycan. Testican-1 is a highly conserved, multidomain proteoglycan that is most prominently expressed in the thalamus of the brain, and is upregulated in activated astroglial cells of the cerebrum. Several functions of this gene product have now been demonstrated in vitro including membrane-type matrix metalloproteinase inhibition, cathepsin L inhibition, and low-affinity calcium binding. The purified gene product has been shown to inhibit cell attachment and neurite extensions in culture. Functions of testican in vivo have yet to be demonstrated in knockout mice or other models. Testican has been shown to carry substantial amounts of chondroitin sulfate as well as other oligosaccharides, but the biological significance of these embellishments is not yet known.

In humans there are three testicans:

SPOCK1 (Testican 1)
SPOCK2 (Testican 2)
SPOCK3 (Testican 3)

Protein, glycoconjugate: glycoproteins and glycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20

Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican

HS/CS	Testican Perlecan

CS	Chondroitin sulfate proteoglycans: Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3

KS	Fibromodulin Lumican Keratocan

HS	Syndecan 1

Other

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