Mucin 5AC

Mucin 5AC, oligomeric mucus/gel-forming
Identifiers
Symbols	MUC5AC ; MUC5; TBM; leB; mucin
External IDs	OMIM: 158373 HomoloGene: 137237 GeneCards: MUC5AC Gene
Gene ontology Molecular function • extracellular matrix structural constituent Cellular component • extracellular space • cytoplasm • Golgi lumen • fibril • extracellular exosome Biological process • protein O-linked glycosylation • O-glycan processing • extracellular fibril organization • post-translational protein modification • cellular protein metabolic process • phosphatidylinositol-mediated signaling Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4586	17833
Ensembl	ENSG00000215182	ENSMUSG00000037974
UniProt	P98088	n/a
RefSeq (mRNA)	NM_001304359	NM_010844
RefSeq (protein)	NP_001291288	NP_034974
Location (UCSC)	Chr 11: 1.16 – 1.2 Mb	Chr 7: 141.79 – 141.82 Mb
PubMed search

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.^[1][2][3]

Clinical relevance

This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD).^[4]

References

1. Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332.
2. van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
3. "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
4. Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med Genomics 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.