Mucin 17
| Mucin 17, cell surface associated | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MUC17 ; MUC3 | ||||||||||||
| External IDs | OMIM: 608424 MGI: 1203527 HomoloGene: 134646 GeneCards: MUC17 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 140453 | n/a | |||||||||||
| Ensembl | ENSG00000169876 | n/a | |||||||||||
| UniProt | Q685J3 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001004430 | n/a | |||||||||||
| RefSeq (protein) | NP_001035194 | n/a | |||||||||||
| Location (UCSC) |
Chr 7: 101.02 – 101.06 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Mucin-17 is a protein that in humans is encoded by the MUC17 gene.[1][2]
Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM][2]
References
- ↑ Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE, Kim YS (Feb 2002). "MUC17, a novel membrane-tethered mucin". Biochem Biophys Res Commun 291 (3): 466–475. doi:10.1006/bbrc.2002.6475. PMID 11855812.
- 1 2 "Entrez Gene: MUC17 mucin 17, cell surface associated".
Further reading
- Kitamoto S, Yamada N, Yokoyama S, et al. (2011). "DNA methylation and histone H3-K9 modifications contribute to MUC17 expression". Glycobiology 21 (2): 247–56. doi:10.1093/glycob/cwq155. PMC 3010767. PMID 20926598.
- Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine". Biochem. J. 410 (2): 283–9. doi:10.1042/BJ20071068. PMID 17990980.
- Moniaux N, Junker WM, Singh AP, et al. (2006). "Characterization of human mucin MUC17. Complete coding sequence and organization". J. Biol. Chem. 281 (33): 23676–23685. doi:10.1074/jbc.M600302200. PMID 16737958.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Ho JJ, Jaituni RS, Crawley SC, et al. (2004). "N-glycosylation is required for the surface localization of MUC17 mucin". Int. J. Oncol. 23 (3): 585–92. doi:10.3892/ijo.23.3.585. PMID 12888891.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wang R, Khatri IA, Forstner JF (2002). "C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components". Biochem. J. 366 (Pt 2): 623–31. doi:10.1042/BJ20020289. PMC 1222797. PMID 12027806.
- Van Klinken BJ, Van Dijken TC, Oussoren E, et al. (1997). "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region". Biochem. Biophys. Res. Commun. 238 (1): 143–148. doi:10.1006/bbrc.1997.7258. PMID 9299468.
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