CSPG5

Chondroitin sulfate proteoglycan 5 (neuroglycan C)
Identifiers
Symbols	CSPG5 ; NGC
External IDs	OMIM: 606775 MGI: 1352747 HomoloGene: 4795 GeneCards: CSPG5 Gene
Gene ontology Molecular function • protein binding • growth factor activity Cellular component • extracellular region • endoplasmic reticulum membrane • Golgi apparatus • Golgi lumen • integral component of plasma membrane • membrane • integral component of membrane • Golgi-associated vesicle membrane • lysosomal lumen Biological process • positive regulation of defense response to virus by host • carbohydrate metabolic process • nervous system development • cell differentiation • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • chondroitin sulfate biosynthetic process • chondroitin sulfate catabolic process • dermatan sulfate biosynthetic process • regulation of growth • small molecule metabolic process • intracellular transport • modulation of synaptic transmission • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10675	29873
Ensembl	ENSG00000114646	ENSMUSG00000032482
UniProt	O95196	Q71M36
RefSeq (mRNA)	NM_001206942	NM_001166273
RefSeq (protein)	NP_001193871	NP_001159745
Location (UCSC)	Chr 3: 47.56 – 47.58 Mb	Chr 9: 110.24 – 110.26 Mb
PubMed search

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.^[1][2]

Interactions

CSPG5 has been shown to interact with GOPC.^[3]

References

1. Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A (May 1999). "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module". Neurosci Res 32 (4): 313–22. doi:10.1016/S0168-0102(98)00098-4. PMID 9950058.
2. "Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)".
3. Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. (United States) 278 (41): 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772.

Further reading

• Ichihara-Tanaka K, Oohira A, Rumsby M, Muramatsu T (2006). "Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.". J. Biol. Chem. 281 (41): 30857–64. doi:10.1074/jbc.M602228200. PMID 16901907.
• Aono S, Tokita Y, Yasuda Y; et al. (2006). "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain.". J. Neurosci. Res. 83 (1): 110–8. doi:10.1002/jnr.20698. PMID 16299773.
• Kinugasa Y, Ishiguro H, Tokita Y; et al. (2004). "Neuroglycan C, a novel member of the neuregulin family.". Biochem. Biophys. Res. Commun. 321 (4): 1045–9. doi:10.1016/j.bbrc.2004.07.066. PMID 15358134.
• Hassel B, Schreff M, Stube EM; et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST.". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.