MMP28
| Matrix metallopeptidase 28 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MMP28 ; EPILYSIN; MM28; MMP-25; MMP-28; MMP25 | ||||||||||||
| External IDs | OMIM: 608417 MGI: 2153062 HomoloGene: 41559 ChEMBL: 4870 GeneCards: MMP28 Gene | ||||||||||||
| EC number | 3.4.24.- | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 79148 | 118453 | |||||||||||
| Ensembl | ENSG00000271447 | ENSMUSG00000020682 | |||||||||||
| UniProt | Q9H239 | Q5SSG2 | |||||||||||
| RefSeq (mRNA) | NM_001032278 | NM_080453 | |||||||||||
| RefSeq (protein) | NP_001027449 | NP_536701 | |||||||||||
| Location (UCSC) |
Chr 17: 35.76 – 35.8 Mb |
Chr 11: 83.44 – 83.46 Mb | |||||||||||
| PubMed search | |||||||||||||
Matrix metalloproteinase 28 also known as epilysin is an enzyme that in humans is encoded by the MMP28 gene.[1][2][3]
Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described.[3]
References
- ↑ Lohi J, Wilson CL, Roby JD, Parks WC (Mar 2001). "Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury". J Biol Chem 276 (13): 10134–44. doi:10.1074/jbc.M001599200. PMID 11121398.
- ↑ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
- 1 2 "Entrez Gene: MMP28 matrix metallopeptidase 28".
Further reading
- Illman SA, Keski-Oja J, Lohi J (2001). "Promoter characterization of the human and mouse epilysin (MMP-28) genes". Gene 275 (1): 185–94. doi:10.1016/S0378-1119(01)00664-3. PMID 11574168.
- Saarialho-Kere U, Kerkelä E, Jahkola T, et al. (2002). "Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair". J. Invest. Dermatol. 119 (1): 14–21. doi:10.1046/j.1523-1747.2002.01790.x. PMID 12164918.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Bar-Or A, Nuttall RK, Duddy M, et al. (2003). "Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis". Brain 126 (Pt 12): 2738–49. doi:10.1093/brain/awg285. PMID 14506071.
- Kevorkian L, Young DA, Darrah C, et al. (2004). "Expression profiling of metalloproteinases and their inhibitors in cartilage". Arthritis Rheum. 50 (1): 131–41. doi:10.1002/art.11433. PMID 14730609.
- Bister VO, Salmela MT, Karjalainen-Lindsberg ML, et al. (2004). "Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer". Dig. Dis. Sci. 49 (4): 653–61. doi:10.1023/B:DDAS.0000026314.12474.17. PMID 15185874.
- Momohara S, Okamoto H, Komiya K, et al. (2005). "Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et al". Arthritis Rheum. 50 (12): 4074–5; author reply 4075. doi:10.1002/art.20799. PMID 15593191.
- Renò F, Sabbatini M, Stella M, et al. (2005). "Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars". Wound Repair and Regeneration 13 (3): 255–61. doi:10.1111/j.1067-1927.2005.130307.x. PMID 15953044.
External links
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