MS4A2

Membrane-spanning 4-domains, subfamily A, member 2

Identifiers

MS4A2 ; APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1

External IDs

OMIM: 147138 MGI: 95495 HomoloGene: 112 GeneCards: MS4A2 Gene

Gene ontology
Molecular function	• IgE receptor activity • IgE binding • protein kinase binding • SH2 domain binding • phosphoprotein binding
Cellular component	• endosome • plasma membrane • integral component of plasma membrane • external side of plasma membrane • Fc-epsilon receptor I complex • membrane raft
Biological process	• inflammatory response • immune response • activation of phospholipase C activity • protein kinase C-activating G-protein coupled receptor signaling pathway • Fc-epsilon receptor signaling pathway • positive regulation of mast cell degranulation • innate immune response • cytokine secretion • regulation of release of sequestered calcium ion into cytosol
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
60.09 – 60.1 Mb

Chr 19:
11.62 – 11.62 Mb

PubMed search

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.^[1]^[2]

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.^[2]

References

↑ Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett 302 (2): 161–5. doi:10.1016/0014-5793(92)80430-O. PMID 1386024.
1 2 "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)".

Jouvin MH, Numerof RP, Kinet JP (1995). "Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI.". Semin. Immunol. 7 (1): 29–35. doi:10.1016/1044-5323(95)90005-5. PMID 7612892.
Wilson BS, Pfeiffer JR, Oliver JM (2003). "FcepsilonRI signaling observed from the inside of the mast cell membrane.". Mol. Immunol. 38 (16-18): 1259–68. doi:10.1016/S0161-5890(02)00073-1. PMID 12217393.
Kraft S, Rana S, Jouvin MH, Kinet JP (2004). "The role of the FcepsilonRI beta-chain in allergic diseases.". Int. Arch. Allergy Immunol. 135 (1): 62–72. doi:10.1159/000080231. PMID 15316148.
Bieber T, de la Salle H, Wollenberg A, et al. (1992). "Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).". J. Exp. Med. 175 (5): 1285–90. doi:10.1084/jem.175.5.1285. PMC 2119213. PMID 1533242.
Küster H, Zhang L, Brini AT, et al. (1992). "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.". J. Biol. Chem. 267 (18): 12782–7. PMID 1535625.
Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23.". Immunogenetics 32 (3): 183–6. doi:10.1007/BF02114971. PMID 2146219.
Tedder TF, Streuli M, Schlossman SF, Saito H (1988). "Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 85 (1): 208–12. doi:10.1073/pnas.85.1.208. PMC 279513. PMID 2448768.
Paolini R, Renard V, Vivier E, et al. (1995). "Different roles for the Fc epsilon RI gamma chain as a function of the receptor context.". J. Exp. Med. 181 (1): 247–55. doi:10.1084/jem.181.1.247. PMC 2191817. PMID 7528770.
Shirakawa T, Li A, Dubowitz M, et al. (1994). "Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.". Nat. Genet. 7 (2): 125–9. doi:10.1038/ng0694-125. PMID 7920628.
Kihara H, Siraganian RP (1994). "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.". J. Biol. Chem. 269 (35): 22427–32. PMID 8071371.
Sandford AJ, Shirakawa T, Moffatt MF, et al. (1993). "Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.". Lancet 341 (8841): 332–4. doi:10.1016/0140-6736(93)90136-5. PMID 8094113.
Szepetowski P, Gaudray P (1994). "FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1.". Genomics 19 (2): 399–400. doi:10.1006/geno.1994.1083. PMID 8188278.
Daniels SE, Bhattacharrya S, James A, et al. (1996). "A genome-wide search for quantitative trait loci underlying asthma.". Nature 383 (6597): 247–50. doi:10.1038/383247a0. PMID 8805698.
Hill MR, Cookson WO (1997). "A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.". Hum. Mol. Genet. 5 (7): 959–62. doi:10.1093/hmg/5.7.959. PMID 8817330.
Shirakawa T, Mao XQ, Sasaki S, et al. (1997). "Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.". Hum. Mol. Genet. 5 (8): 1129–30. doi:10.1093/hmg/5.8.1129. PMID 8842731.
Shirakawa T, Mao XQ, Sasaki S, et al. (1997). "Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.". Hum. Mol. Genet. 5 (12): 2068. PMID 8968765.
Hendricks-Taylor LR, Motto DG, Zhang J, et al. (1997). "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.". J. Biol. Chem. 272 (2): 1363–7. doi:10.1074/jbc.272.2.1363. PMID 8995445.
Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein.". J. Biol. Chem. 272 (23): 14733–9. doi:10.1074/jbc.272.23.14733. PMID 9169438.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)

Arrestin	SAG ARRB1 ARRB2 ARR3

Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18

Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero

Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C

Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34

Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF

see also other cell membrane protein disorders

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MS4A2

Function

See also

References

Further reading