TSPAN2
| Tetraspanin 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TSPAN2 ; NET3; TSN2; TSPAN-2 | ||||||||||||
| External IDs | OMIM: 613133 MGI: 1917997 HomoloGene: 21169 GeneCards: TSPAN2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10100 | 70747 | |||||||||||
| Ensembl | ENSG00000134198 | ENSMUSG00000027858 | |||||||||||
| UniProt | O60636 | Q922J6 | |||||||||||
| RefSeq (mRNA) | NM_001308315 | NM_001243132 | |||||||||||
| RefSeq (protein) | NP_001295244 | NP_001230061 | |||||||||||
| Location (UCSC) |
Chr 1: 115.05 – 115.09 Mb |
Chr 3: 102.73 – 102.8 Mb | |||||||||||
| PubMed search | |||||||||||||
Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.[1][2][3]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[3]
References
- ↑ Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
- ↑ Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci 114 (Pt 23): 4143–51. PMID 11739647.
- 1 2 "Entrez Gene: TSPAN2 tetraspanin 2".
Further reading
- Hemler ME (2002). "Specific tetraspanin functions". J. Cell Biol. 155 (7): 1103–7. doi:10.1083/jcb.200108061. PMC 2199333. PMID 11756464.
- Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
External links
- TSPAN2 human gene location in the UCSC Genome Browser.
- TSPAN2 human gene details in the UCSC Genome Browser.
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