TSPAN8

Tetraspanin 8
Identifiers
Symbols	TSPAN8 ; CO-029; TM4SF3
External IDs	OMIM: 600769 MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8 Gene
Gene ontology Molecular function • integrin binding Cellular component • integral component of membrane • extracellular exosome Biological process • negative regulation of blood coagulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7103	216350
Ensembl	ENSG00000127324	ENSMUSG00000034127
UniProt	P19075	Q8R3G9
RefSeq (mRNA)	NM_004616	NM_001168679
RefSeq (protein)	NP_004607	NP_001162150
Location (UCSC)	Chr 12: 71.13 – 71.44 Mb	Chr 10: 115.82 – 115.85 Mb
PubMed search

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.^[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.^[2]

References

1. Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (Oct 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proc Natl Acad Sci U S A 87 (17): 6833–7. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876.
2. "Entrez Gene: TSPAN8 tetraspanin 8".

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gwynn B, Eicher EM, Peters LL (1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
• Kanetaka K, Sakamoto M, Yamamoto Y, et al. (2002). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma". J. Hepatol. 35 (5): 637–42. doi:10.1016/S0168-8278(01)00183-0. PMID 11690710.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shackel NA, McGuinness PH, Abbott CA, et al. (2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization". Hepatology 38 (3): 577–88. doi:10.1053/jhep.2003.50376. PMID 12939584.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kuhn S, Koch M, Nübel T, et al. (2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Mol. Cancer Res. 5 (6): 553–67. doi:10.1158/1541-7786.MCR-06-0384. PMID 17579117.