ARR3

Arrestin 3, retinal (X-arrestin)
Rendering based on PDB 1XEH​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1XEH​, 2A34​
Identifiers
Symbols	ARR3 ; ARRX
External IDs	OMIM: 301770 MGI: 2159617 HomoloGene: 3182 GeneCards: ARR3 Gene
Gene ontology Molecular function • opsin binding • protein binding • protein domain specific binding • phosphoprotein binding Cellular component • photoreceptor outer segment • photoreceptor inner segment • cytoplasm • synapse Biological process • regulation of protein phosphorylation • endocytosis • signal transduction • visual perception Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	407	170735
Ensembl	ENSG00000120500	ENSMUSG00000060890
UniProt	P36575	Q9EQP6
RefSeq (mRNA)	NM_004312	NM_133205
RefSeq (protein)	NP_004303	NP_573468
Location (UCSC)	Chr X: 70.27 – 70.28 Mb	Chr X: 100.61 – 100.62 Mb
PubMed search

Arrestin-C also known as retinal cone arrestin-3 is a protein that in humans is encoded by the ARR3 gene.^[1][2]

See also

• arrestin

References

1. Murakami A, Yajima T, Sakuma H, McLaren MJ, Inana G (Dec 1993). "X-arrestin: a new retinal arrestin mapping to the X chromosome". FEBS Lett 334 (2): 203–9. doi:10.1016/0014-5793(93)81712-9. PMID 8224247.
2. "Entrez Gene: ARR3 arrestin 3, retinal (X-arrestin)".

Further reading

• Craft CM, Whitmore DH, Wiechmann AF (1994). "Cone arrestin identified by targeting expression of a functional family.". J. Biol. Chem. 269 (6): 4613–9. PMID 8308033.
• Sakuma H, Inana G, Murakami A; et al. (1996). "Immunolocalization of X-arrestin in human cone photoreceptors.". FEBS Lett. 382 (1-2): 105–10. doi:10.1016/0014-5793(96)00163-9. PMID 8612728.
• ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.". Cell 95 (4): 563–73. doi:10.1016/S0092-8674(00)81623-2. PMID 9827808.
• Orsini MJ, Benovic JL (1999). "Characterization of dominant negative arrestins that inhibit beta2-adrenergic receptor internalization by distinct mechanisms.". J. Biol. Chem. 273 (51): 34616–22. doi:10.1074/jbc.273.51.34616. PMID 9852134.
• Sakuma H, Murakami A, Fujimaki T, Inana G (1999). "Isolation and characterization of the human X-arrestin gene.". Gene 224 (1-2): 87–95. doi:10.1016/S0378-1119(98)00510-1. PMID 9931451.
• John SK, Smith JE, Aguirre GD, Milam AH (2000). "Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa.". Mol. Vis. 6: 204–15. PMID 11063754.
• Chen Z, Dupré DJ, Le Gouill C; et al. (2002). "Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif.". J. Biol. Chem. 277 (9): 7356–62. doi:10.1074/jbc.M110058200. PMID 11729201.
• Kim YM, Barak LS, Caron MG, Benovic JL (2002). "Regulation of arrestin-3 phosphorylation by casein kinase II.". J. Biol. Chem. 277 (19): 16837–46. doi:10.1074/jbc.M201379200. PMID 11877451.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu X, Li A, Brown B; et al. (2002). "Mouse cone arrestin expression pattern: light induced translocation in cone photoreceptors.". Mol. Vis. 8: 462–71. PMID 12486395.
• Zhang H, Cuenca N, Ivanova T; et al. (2003). "Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6.". Invest. Ophthalmol. Vis. Sci. 44 (7): 2858–67. doi:10.1167/iovs.03-0072. PMID 12824223.
• Krishnamurthy H, Galet C, Ascoli M (2004). "The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation.". Mol. Cell. Endocrinol. 204 (1-2): 127–40. doi:10.1016/S0303-7207(03)00088-1. PMID 12850288.
• Zhu X, Brown B, Li A; et al. (2003). "GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.". J. Neurosci. 23 (14): 6152–60. PMID 12853434.
• Ermakova NA, Alekberova ZS, Prokaeva TB (2003). "Autoimmunity to S-antigen and retinal vasculitis in patients with Behçet's disease.". Adv. Exp. Med. Biol. 528: 279–81. doi:10.1007/0-306-48382-3_56. PMID 12918707.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.