Corticorelin

Corticorelin

Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	79804-71-0
ATC code	V04CD04
PubChem	CID 16132344
UNII	305OE8862Y
Chemical data
Formula	C205H339N59O63S
Molar mass	4670.31 g/mol
(verify)

Corticorelin (INN) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).^[1]

The corticorelin stimulation test helps to differentiate between the etiologies of adrenocorticotropic hormone (ACTH)-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

• If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
• If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of ectopic ACTH syndrome is confirmed.

See also

• ACTH stimulation test
• Dexamethasone suppression test
• Metyrapone
• Tetracosactide

References

1. Andoh K, Kimura T, Saeki I; et al. (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung 44 (6): 715–26. PMID 8053970.