Neuropeptide Y receptor Y5

Neuropeptide Y receptor Y5
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2HE6​
Identifiers
Symbols	NPY5R ; NPY5-R; NPYR5; NPYY5-R
External IDs	OMIM: 602001 MGI: 108082 HomoloGene: 21241 IUPHAR: 308 ChEMBL: 4561 GeneCards: NPY5R Gene
Gene ontology Molecular function • peptide YY receptor activity • pancreatic polypeptide receptor activity • neuropeptide Y receptor activity Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • neuron projection Biological process • positive regulation of acute inflammatory response • outflow tract morphogenesis • cardiac left ventricle morphogenesis • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • synaptic transmission • negative regulation of glutamate secretion • negative regulation of synaptic transmission, GABAergic • eating behavior • negative regulation of apoptotic process • positive regulation of smooth muscle cell proliferation • generation of ovulation cycle rhythm Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4889	18168
Ensembl	ENSG00000164129	ENSMUSG00000044014
UniProt	Q15761	O70342
RefSeq (mRNA)	NM_006174	NM_016708
RefSeq (protein)	NP_006165	NP_057917
Location (UCSC)	Chr 4: 163.34 – 163.35 Mb	Chr 8: 66.68 – 66.69 Mb
PubMed search

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.^[1][2][3]

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• BWX-46 (selective NPY₅ agonist, CAS# 172997-92-1)
• Peptide YY

Antagonists

• CGP-71683 (CAS# 192322-50-2)
• FMS-586^[4]
• L-152,804 (CAS# 6508-43-6)
• Lu AA-33810^[5]
• MK-0557^[6]
• NTNCB (CAS# 486453-65-0)^[7]
• Velneperit (S-2367)

See also

• Neuropeptide Y receptor

References

1. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Jul 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature 382 (6587): 168–71. doi:10.1038/382168a0. PMID 8700207.
2. Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
3. "Entrez Gene: NPY5R neuropeptide Y receptor Y5".
4. Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics 317 (2): 562–70. doi:10.1124/jpet.105.099705. PMID 16436501.
5. {{cite journal | vauthors =Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA | title =The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity | journal =The Journal of Pharmacology and Experimental Therapeutics | volume =328 | issue =3 | pages =900–11 | date =Mar 2009 | pmid =19098165 | doi =10.1124/jpet.108.144634 }}
6. MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry 7 (17): 1721–33. doi:10.2174/156802607782341028. PMID 17979781.
7. Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (Jul 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 12 (13): 1767–9. doi:10.1016/S0960-894X(02)00287-1. PMID 12067557.

Further reading

• Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
• Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML (Oct 1996). "Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior". The Journal of Biological Chemistry 271 (42): 26315–9. doi:10.1074/jbc.271.42.26315. PMID 8824284.
• Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J (May 1997). "Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation". Genomics 41 (3): 315–9. doi:10.1006/geno.1997.4684. PMID 9169127.
• Nichol KA, Morey A, Couzens MH, Shine J, Herzog H, Cunningham AM (Dec 1999). "Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control". The Journal of Neuroscience 19 (23): 10295–304. PMID 10575027.
• Rodriguez M, Audinot V, Dromaint S, Macia C, Lamamy V, Beauverger P, Rique H, Imbert J, Nicolas JP, Boutin JA, Galizzi JP (Feb 2003). "Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform". The Biochemical Journal 369 (Pt 3): 667–73. doi:10.1042/BJ20020739. PMC 1223119. PMID 12398768.
• Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (Jul 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.
• Beauverger P, Rodriguez M, Nicolas JP, Audinot V, Lamamy V, Dromaint S, Nagel N, Macia C, Léopold O, Galizzi JP, Caignard DH, Aldana I, Monge A, Chomarat P, Boutin JA (Apr 2005). "Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay". Cellular Signalling 17 (4): 489–96. doi:10.1016/j.cellsig.2004.09.006. PMID 15601626.
• Movafagh S, Hobson JP, Spiegel S, Kleinman HK, Zukowska Z (Sep 2006). "Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors". FASEB Journal 20 (11): 1924–6. doi:10.1096/fj.05-4770fje. PMID 16891622.
• Coletta DK, Schneider J, Stern MP, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP (Apr 2007). "Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans". Obesity 15 (4): 809–15. doi:10.1038/oby.2007.610. PMID 17426313.

External links

• "Neuropeptide Y Receptors: Y₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.