GPR77

Complement component 5a receptor 2
Identifiers
Symbols	C5AR2 ; C5L2; GPF77; GPR77
External IDs	OMIM: 609949 MGI: 2442013 HomoloGene: 49549 IUPHAR: 33 GeneCards: C5AR2 Gene
Gene ontology Molecular function • C5a anaphylatoxin receptor activity • protein binding Cellular component • plasma membrane • basal plasma membrane • integral component of membrane • apical part of cell Biological process • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • negative regulation of tumor necrosis factor production • positive regulation of epithelial cell proliferation • positive regulation of ERK1 and ERK2 cascade • negative regulation of neutrophil chemotaxis • negative regulation of interleukin-6 secretion • regulation of interleukin-8 secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27202	319430
Ensembl	ENSG00000134830	ENSMUSG00000074361
UniProt	Q9P296	Q8BW93
RefSeq (mRNA)	NM_001271749	NM_001146005
RefSeq (protein)	NP_001258678	NP_001139477
Location (UCSC)	Chr 19: 47.33 – 47.35 Mb	Chr 7: 16.23 – 16.24 Mb
PubMed search

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.^[1][2]

Function

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.^[2][3]

References

1. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
2. "HUGO".
3. Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677–80. doi:10.1074/jbc.C500287200. PMID 16204243.

Further reading

• Klos A, Wende E, Wareham KJ, Monk PN. (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
• Ohno M, Hirata T, Enomoto M, et al. (2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells". Mol. Immunol. 37 (8): 407–12. doi:10.1016/S0161-5890(00)00067-5. PMID 11090875.
• Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)". J. Biol. Chem. 277 (9): 7165–9. doi:10.1074/jbc.C100714200. PMID 11773063.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kalant D, Cain SA, Maslowska M, et al. (2003). "The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein". J. Biol. Chem. 278 (13): 11123–9. doi:10.1074/jbc.M206169200. PMID 12540846.
• Otto M, Hawlisch H, Monk PN, et al. (2004). "C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism". J. Biol. Chem. 279 (1): 142–51. doi:10.1074/jbc.M310078200. PMID 14570896.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Huber-Lang M, Sarma JV, Rittirsch D, et al. (2005). "Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans". J. Immunol. 174 (2): 1104–10. doi:10.4049/jimmunol.174.2.1104. PMID 15634936.
• Kalant D, MacLaren R, Cui W, et al. (2005). "C5L2 is a functional receptor for acylation-stimulating protein". J. Biol. Chem. 280 (25): 23936–44. doi:10.1074/jbc.M406921200. PMID 15833747.
• Johswich K, Martin M, Thalmann J, et al. (2007). "Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines". J. Biol. Chem. 281 (51): 39088–95. doi:10.1074/jbc.M609734200. PMID 17068344.
• Scola AM, Higginbottom A, Partridge LJ, et al. (2007). "THE ROLE OF THE N-TERMINAL DOMAIN OF THE COMPLEMENT FRAGMENT RECEPTOR, C5L2, IN LIGAND BINDING". J. Biol. Chem. 282 (6): 3664–71. doi:10.1074/jbc.M609178200. PMC 2873560. PMID 17158873.

External links

• "Complement Peptide Receptors: C5a2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.