GPRC6A
| G protein-coupled receptor, class C, group 6, member A | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | GPRC6A ; GPCR; bA86F4.3 | ||||||||||||
| External IDs | OMIM: 613572 MGI: 2429498 HomoloGene: 17529 IUPHAR: 55 GeneCards: GPRC6A Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 222545 | 210198 | |||||||||||
| Ensembl | ENSG00000173612 | ENSMUSG00000019905 | |||||||||||
| UniProt | Q5T6X5 | Q8K4Z6 | |||||||||||
| RefSeq (mRNA) | NM_001286354 | NM_153071 | |||||||||||
| RefSeq (protein) | NP_001273283 | NP_694711 | |||||||||||
| Location (UCSC) |
Chr 6: 116.79 – 116.83 Mb |
Chr 10: 51.61 – 51.63 Mb | |||||||||||
| PubMed search | |||||||||||||
G protein-coupled receptor family C group 6 member A is a protein that in humans is encoded by the GPRC6A gene.[1] This receptor functions as a sensor of L-amino acids,[2] calcium,[3] osteocalcin,[4] and steroids.[5]
Clinical significance
GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.[6]
References
- ↑ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
- ↑ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
- ↑ Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol Chem 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.
- ↑ Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMID 21425331.
- ↑ Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC 3000977. PMID 20947496.
- ↑ Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate 72 (4): 399–409. doi:10.1002/pros.21442. PMID 21681779.
Further reading
- Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.
- Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
- Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.
External links
- GPRC6A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Calcium-Sensing Receptors: GPRC6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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