Somatostatin receptor 3

Somatostatin receptor 3
Identifiers
Symbols	SSTR3 ; SS-3-R; SS3-R; SS3R; SSR-28
External IDs	OMIM: 182453 MGI: 98329 HomoloGene: 20285 IUPHAR: 357 ChEMBL: 2028 GeneCards: SSTR3 Gene
Gene ontology Molecular function • somatostatin receptor activity • protein binding Cellular component • cytoplasm • plasma membrane • integral component of plasma membrane • nonmotile primary cilium • ciliary membrane Biological process • organelle organization • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell-cell signaling • spermatogenesis • negative regulation of cell proliferation • hormone-mediated apoptotic signaling pathway • cerebellum development • forebrain development • somatostatin signaling pathway • response to starvation • cellular response to glucocorticoid stimulus • cellular response to estradiol stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6753	20607
Ensembl	ENSG00000278195	ENSMUSG00000044933
UniProt	P32745	P30935
RefSeq (mRNA)	NM_001051	NM_009218
RefSeq (protein)	NP_001042	NP_033244
Location (UCSC)	Chr 22: 37.2 – 37.21 Mb	Chr 15: 78.54 – 78.54 Mb
PubMed search

Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.^[1][2]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.^[2]

See also

• Somatostatin receptor

References

1. Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–452. doi:10.1006/geno.1993.1088. PMID 8449518.
2. "Entrez Gene: SSTR3 somatostatin receptor 3".

Further reading

• Yamada Y, Reisine T, Law SF, et al. (1993). "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase". Mol. Endocrinol. 6 (12): 2136–2142. doi:10.1210/me.6.12.2136. PMID 1337145.
• Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–255. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
• Corness JD, Demchyshyn LL, Seeman P, et al. (1993). "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides". FEBS Lett. 321 (2–3): 279–284. doi:10.1016/0014-5793(93)80124-D. PMID 8097479.
• Law SF, Zaina S, Sweet R, et al. (1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Mol. Pharmacol. 45 (4): 587–90. PMID 8183236.
• Kaupmann K, Bruns C, Hoyer D, et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1–2): 53–59. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.
• Sharma K, Patel YC, Srikant CB (1997). "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3". Mol. Endocrinol. 10 (12): 1688–1696. doi:10.1210/me.10.12.1688. PMID 8961277.
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–163. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–1862. doi:10.1210/jc.82.6.1857. PMID 9177396.
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997). "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization". J. Biol. Chem. 272 (38): 23769–23774. doi:10.1074/jbc.272.38.23769. PMID 9295322.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208.
• Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–2169. doi:10.1210/jc.86.5.2161. PMID 11344221.
• Talme T, Ivanoff J, Hägglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–79. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
• Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–475. doi:10.1007/s00428-002-0609-x. PMID 12021920.
• Ferone D, Pivonello R, Van Hagen PM, et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335.
• Pasquali D, Notaro A, Bonavolonta' G, et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". J. Clin. Endocrinol. Metab. 87 (11): 5125–5129. doi:10.1210/jc.2002-020790. PMID 12414882.
• Dizeyi N, Konrad L, Bjartell A, et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urol. Oncol. 7 (3): 91–98. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• "Somatostatin Receptors: sst₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• somatostatin receptor 3 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.