GPR177

Wntless Wnt ligand secretion mediator
Identifiers
Symbols	WLS ; C1orf139; EVI; GPR177; MRP; mig-14
External IDs	OMIM: 611514 MGI: 1915401 HomoloGene: 11779 GeneCards: WLS Gene
Gene ontology Molecular function • signal transducer activity • protein binding • Wnt-protein binding • mu-type opioid receptor binding Cellular component • Golgi membrane • plasma membrane • integral component of membrane • cytoplasmic vesicle membrane • early endosome membrane • dendrite membrane • dendrite cytoplasm Biological process • mesoderm formation • anterior/posterior axis specification • Wnt signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79971	68151
Ensembl	ENSG00000116729	ENSMUSG00000028173
UniProt	Q5T9L3	Q6DID7
RefSeq (mRNA)	NM_001002292	NM_026582
RefSeq (protein)	NP_001002292	NP_080858
Location (UCSC)	Chr 1: 68.1 – 68.23 Mb	Chr 3: 159.84 – 159.94 Mb
PubMed search

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene^[1] that encodes a receptor for Wnt proteins in Wnt-secreting cells.^[2]

Wntless was shown to be a cargo for the retromer complex.^[2] It has been found essential for hair follicle induction.^[3]

References

1. "Entrez Gene: GPR177 G protein-coupled receptor 177".
2. Eaton S (January 2008). "Retromer retrieves wntless". Dev. Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
3. Fu, J.; Hsu, W. (2012). "Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis". Journal of Investigative Dermatology 133 (4): 890–8. doi:10.1038/jid.2012.407. PMID 23190887.

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Bänziger C, Soldini D, Schütt C, et al. (2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.". Cell 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

See also

• GPR177 receptor, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.