C3a receptor

Complement component 3a receptor 1
Identifiers
Symbols	C3AR1 ; AZ3B; C3AR; HNFAG09
External IDs	OMIM: 605246 MGI: 1097680 HomoloGene: 2992 IUPHAR: 31 ChEMBL: 4761 GeneCards: C3AR1 Gene
Gene ontology Molecular function • complement component C3a binding • phosphatidylinositol phospholipase C activity • complement component C3a receptor activity • G-protein coupled receptor activity • C3a anaphylatoxin receptor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • complement receptor mediated signaling pathway • tolerance induction to nonself antigen • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • blood circulation • regulation of blood pressure • positive regulation of vascular endothelial growth factor production • positive regulation of macrophage chemotaxis • positive regulation of angiogenesis • positive regulation of smooth muscle cell proliferation • positive regulation of glomerular mesangial cell proliferation • positive regulation of neutrophil chemotaxis • positive regulation of DNA biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	719	12267
Ensembl	ENSG00000171860	ENSMUSG00000040552
UniProt	Q16581	O09047
RefSeq (mRNA)	NM_004054	NM_009779
RefSeq (protein)	NP_004045	NP_033909
Location (UCSC)	Chr 12: 8.06 – 8.07 Mb	Chr 6: 122.85 – 122.86 Mb
PubMed search

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.^[1][2]

Although its official name implies it only binds C3a, it also binds C4a.^[3]

References

1. Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
2. Ali H, Panettieri RA (2005). "Anaphylatoxin C3a receptors in asthma". Respir. Res. 6: 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.
3. Klos A, Wende E, Wareham KJ, Monk PN. (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.

Further reading

• Sim RB, Laich A (2001). "Serine proteases of the complement system". Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Roglic A, Prossnitz ER, Cavanagh SL; et al. (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
• Ames RS, Li Y, Sarau HM; et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". J. Biol. Chem. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.
• Crass T, Raffetseder U, Martin U; et al. (1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". Eur. J. Immunol. 26 (8): 1944–50. doi:10.1002/eji.1830260840. PMID 8765043.
• Ames RS, Nuthulaganti P, Kumar C (1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Lett. 395 (2–3): 157–9. doi:10.1016/0014-5793(96)01018-6. PMID 8898085.
• Martin U, Bock D, Arseniev L; et al. (1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". J. Exp. Med. 186 (2): 199–207. doi:10.1084/jem.186.2.199. PMC 2198980. PMID 9221749.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hollmann TJ, Haviland DL, Kildsgaard J; et al. (1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Mol. Immunol. 35 (3): 137–48. doi:10.1016/S0161-5890(98)00021-2. PMID 9694514.
• Lienenklaus S, Ames RS, Tornetta MA; et al. (1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". J. Immunol. 161 (5): 2089–93. PMID 9725198.
• Davoust N, Jones J, Stahel PF; et al. (1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia 26 (3): 201–11. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761.
• Settmacher B, Bock D, Saad H; et al. (1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". J. Immunol. 162 (12): 7409–16. PMID 10358194.
• Feild JA, Foley JJ, Testa TT; et al. (1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Lett. 460 (1): 53–6. doi:10.1016/S0014-5793(99)01317-4. PMID 10571060.
• Petering H, Köhl J, Weyergraf A; et al. (2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". J. Immunol. 164 (7): 3783–9. doi:10.4049/jimmunol.164.7.3783. PMID 10725738.
• Drouin SM, Kildsgaard J, Haviland J; et al. (2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". J. Immunol. 166 (3): 2025–32. doi:10.4049/jimmunol.166.3.2025. PMID 11160252.
• Ames RS, Lee D, Foley JJ; et al. (2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". J. Immunol. 166 (10): 6341–8. doi:10.4049/jimmunol.166.10.6341. PMID 11342658.
• Kirchhoff K, Weinmann O, Zwirner J; et al. (2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology 103 (2): 210–7. doi:10.1046/j.1365-2567.2001.01197.x. PMC 1783227. PMID 11412308.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Reca R, Mastellos D, Majka M; et al. (2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood 101 (10): 3784–93. doi:10.1182/blood-2002-10-3233. PMID 12511407.

External links

• "Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• C3AR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)