C8 complex

High Resolution Crystal Structure of Human Complement Component 8

complement component 8, alpha polypeptide
Identifiers
Symbol	C8A
Entrez	731
HUGO	1352
OMIM	120950
RefSeq	NM_000562
UniProt	P07357
Other data
Locus	Chr. 1 p36.2-22.1

complement component 8, beta polypeptide
Identifiers
Symbol	C8B
Entrez	732
HUGO	1353
OMIM	1209660
RefSeq	NM_000066
UniProt	P073o58
Other data
Locus	Chr. 1 p36.2-22.1

complement component 8, gamma polypeptide
Identifiers
Symbol	C8G
Entrez	733
HUGO	1354
OMIM	120930
RefSeq	NM_000606
UniProt	P07360
Other data
Locus	Chr. 9 q34.3

Complement component 8 is a protein involved in the complement system. A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Membrane attack complex. Some labels are in Polish.

References

1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol

External links

Complement C8 at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteins: complement system (C, L, A)

Activators/enzymes

Early	C: C1Q/C1R/C1S C4 C4a C4b C2 L: MASP1/MASP2 MBL A: Factor B Factor D Factor P/Properdin

Middle	C3 C3a C3b/iC3b C5 C5a C3-convertase C5-convertase

Late	MAC C6 C7 C8 C9

Inhibitors

CL: C4BP

A: Factor H

Complement receptors

The crystal structure is now in the PDB, PDB ID 3OJY.

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