C8 complex

High Resolution Crystal Structure of Human Complement Component 8
complement component 8, alpha polypeptide
Identifiers
Symbol C8A
Entrez 731
HUGO 1352
OMIM 120950
RefSeq NM_000562
UniProt P07357
Other data
Locus Chr. 1 p36.2-22.1
complement component 8, beta polypeptide
Identifiers
Symbol C8B
Entrez 732
HUGO 1353
OMIM 1209660
RefSeq NM_000066
UniProt P073o58
Other data
Locus Chr. 1 p36.2-22.1
complement component 8, gamma polypeptide
Identifiers
Symbol C8G
Entrez 733
HUGO 1354
OMIM 120930
RefSeq NM_000606
UniProt P07360
Other data
Locus Chr. 9 q34.3

Complement component 8 is a protein involved in the complement system. A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Membrane attack complex. Some labels are in Polish.

References

1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol

External links

The crystal structure is now in the PDB, PDB ID 3OJY.


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