Complement receptor

A complement receptor is a receptor of the complement system, a part of the mediated innate immune system. Complement receptors are responsible for detecting pathogens by mechanisms not mediated by antibodies. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore, complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.

Complement receptors

Types include:

CR #	Name	CD
CR1	-	CD35
CR2	-	CD21
CR3	Macrophage-1 antigen or "integrin alphaMbeta2"	CD11b+CD18
CR4	Integrin alphaXbeta2 or "p150,95"	CD11c+CD18
-	C3a receptor	-
-	C5a receptor	CD88

Clinical significance

Defects in these receptors can be associated with disease.^[1]

References

↑ "Complement Receptor Deficiency: eMedicine Dermatology". Retrieved 2010-12-07.

External links

Complement receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteins: complement system (C, L, A)

Activators/enzymes

Early	C: C1Q/C1R/C1S C4 C4a C4b C2 L: MASP1/MASP2 MBL A: Factor B Factor D Factor P/Properdin

Middle	C3 C3a C3b/iC3b C5 C5a C3-convertase C5-convertase

Late	MAC C6 C7 C8 C9

Inhibitors

CL: C4BP

A: Factor H

Complement receptors

Innate immune system: Pattern recognition receptors

Membrane-bound_PRRs	Toll-like receptor Mannose receptor Formyl peptide receptor Scavenger receptor

Cytoplasmic_PRRs	Toll-like receptor NOD-like receptor RIG-I-like receptor Scavenger receptor

Secreted_PRRs	Complement receptor Collectin

Other/ungrouped	Immunophilins (Cyclophilin)

This article is issued from Wikipedia - version of the Thursday, September 10, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

Complement receptor