ADCYAP1R1

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ADCYAP1R1 ; PAC1; PAC1R; PACAPR; PACAPRI
External IDs OMIM: 102981 MGI: 108449 HomoloGene: 870 IUPHAR: 370 ChEMBL: 5399 GeneCards: ADCYAP1R1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 117 11517
Ensembl ENSG00000078549 ENSMUSG00000029778
UniProt P41586 P70205
RefSeq (mRNA) NM_001118 NM_001025372
RefSeq (protein) NP_001109 NP_001020543
Location (UCSC) Chr 7:
31.05 – 31.11 Mb		 Chr 6:
55.45 – 55.5 Mb
PubMed search

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded by the ADCYAP1R1 gene.[1] This receptor binds pituitary adenylate cyclase activating peptide.[2][3]

Function

PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.[1] PAC1 is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.[4][5][6] It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).[7]

References

  1. 1 2 "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".
  2. ↑ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  3. ↑ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews 52 (2): 269–324. PMID 10835102.
  4. ↑ Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences 921: 1–25. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811.
  5. ↑ Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research 60 (11): 3105–12. PMID 10850463.
  6. ↑ Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159.
  7. ↑ Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171.

Further reading

  • Stoffel M, Espinosa R, Trabb JB, Le Beau MM, Bell GI (Oct 1994). "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7". Genomics 23 (3): 697–9. doi:10.1006/geno.1994.1560. PMID 7851900. 
  • Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709. 
  • Ohtaki T, Masuda Y, Ishibashi Y, Kitada C, Arimura A, Fujino M (Dec 1993). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". The Journal of Biological Chemistry 268 (35): 26650–7. PMID 8253796. 
  • Pisegna JR, Wank SA (Jul 1996). "Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C". The Journal of Biological Chemistry 271 (29): 17267–74. doi:10.1074/jbc.271.29.17267. PMID 8663363. 
  • Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, Journot L (Sep 1996). "Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation". The Journal of Biological Chemistry 271 (36): 22146–51. doi:10.1074/jbc.271.36.22146. PMID 8703026. 
  • Solano RM, Carmena MJ, Carrero I, Cavallaro S, Roman F, Hueso C, Travali S, Lopez-Fraile N, Guijarro LG, Prieto JC (Jul 1996). "Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate". Endocrinology 137 (7): 2815–22. doi:10.1210/en.137.7.2815. PMID 8770902. 
  • Wei Y, Mojsov S (Nov 1996). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology". Journal of Neuroendocrinology 8 (11): 811–7. doi:10.1046/j.1365-2826.1996.05191.x. PMID 8933357. 
  • Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S (Nov 1996). "Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization". Genomics 38 (1): 100–2. doi:10.1006/geno.1996.0600. PMID 8954788. 
  • Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159. 
  • Steinhoff M, McGregor GP, Radleff-Schlimme A, Steinhoff A, Jarry H, Schmidt WE (Mar 1999). "Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis". Regulatory Peptides 80 (1-2): 49–55. doi:10.1016/S0167-0115(99)00010-5. PMID 10235634. 
  • Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR (Nov 1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". The Journal of Clinical Investigation 104 (10): 1383–91. doi:10.1172/JCI7537. PMC 409843. PMID 10562300. 
  • Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (Dec 1999). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology 11 (12): 941–9. doi:10.1046/j.1365-2826.1999.00411.x. PMID 10583729. 
  • Scaldaferri ML, Modesti A, Palumbo C, Ulisse S, Fabbri A, Piccione E, Frajese G, Moretti C (Mar 2000). "Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta". Endocrinology 141 (3): 1158–67. doi:10.1210/en.141.3.1158. PMID 10698193. 
  • Busto R, Prieto JC, Bodega G, Zapatero J, Carrero I (Feb 2000). "Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung". Peptides 21 (2): 265–9. doi:10.1016/S0196-9781(99)00202-8. PMID 10764955. 
  • Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171. 
  • Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR (May 2002). "Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons". Regulatory Peptides 105 (3): 145–54. doi:10.1016/S0167-0115(02)00003-4. PMID 11959368. 
  • Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR, Germano P (Nov 2002). "PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells". Regulatory Peptides 109 (1-3): 115–25. doi:10.1016/S0167-0115(02)00194-5. PMID 12409223. 
  • Ronaldson E, Robertson DN, Johnson MS, Holland PJ, Mitchell R, Lutz EM (Nov 2002). "Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF". Regulatory Peptides 109 (1-3): 193–8. doi:10.1016/S0167-0115(02)00204-5. PMID 12409233. 
  • Isobe K, Tatsuno I, Yashiro T, Nanmoku T, Takekoshi K, Kawakami Y, Nakai T (Feb 2003). "Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis". Regulatory Peptides 110 (3): 213–7. doi:10.1016/S0167-0115(02)00209-4. PMID 12573802. 

External links

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