Neurotensin receptor 1

Neurotensin receptor 1 (high affinity)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LYW​
Identifiers
Symbols	NTSR1 ; NTR
External IDs	OMIM: 162651 MGI: 97386 HomoloGene: 68261 IUPHAR: 309 ChEMBL: 4123 GeneCards: NTSR1 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • protein binding • G-protein coupled neurotensin receptor activity • protein homodimerization activity • protein heterodimerization activity • protein N-terminus binding Cellular component • mitochondrion • endoplasmic reticulum • Golgi apparatus • plasma membrane • integral component of plasma membrane • cytoplasmic side of plasma membrane • cell surface • symmetric synapse • terminal bouton • dendritic spine • dendritic shaft • perikaryon • membrane raft Biological process • temperature homeostasis • negative regulation of systemic arterial blood pressure • regulation of membrane depolarization • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • synaptic transmission • learning • adult locomotory behavior • positive regulation of glutamate secretion • positive regulation of gamma-aminobutyric acid secretion • response to lipid • positive regulation of apoptotic process • negative regulation of apoptotic process • regulation of respiratory gaseous exchange • detection of temperature stimulus involved in sensory perception of pain • negative regulation of release of sequestered calcium ion into cytosol • positive regulation of release of sequestered calcium ion into cytosol • regulation of sensory perception of pain • positive regulation of inositol phosphate biosynthetic process • D-aspartate import • inositol phosphate catabolic process • positive regulation of arachidonic acid secretion • positive regulation of inhibitory postsynaptic potential • regulation of action potential • L-glutamate import into cell • positive regulation of cation channel activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4923	18216
Ensembl	ENSG00000101188	ENSMUSG00000027568
UniProt	P30989	O88319
RefSeq (mRNA)	NM_002531	NM_018766
RefSeq (protein)	NP_002522	NP_061236
Location (UCSC)	Chr 20: 62.71 – 62.76 Mb	Chr 2: 180.5 – 180.54 Mb
PubMed search

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene.^[1][2] For a crystal structure of NTS1, see pdb code 4GRV.

Function

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of testing as many as neurotensin, such as low blood pressure, high blood sugar, low body temperature, antinociception, and regulation of intestinal motility and secretion.^[2]

See also

• Neurotensin receptor

References

1. Laurent P, Clerc P, Mattei MG, Forgez P, Dumont X, Ferrara P, Caput D, Rostene W (May 1994). "Chromosomal localization of mouse and human neurotensin receptor genes". Mammalian Genome 5 (5): 303–6. doi:10.1007/BF00389545. PMID 8075503.
2. "Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)".

Further reading

• Vincent JP (Oct 1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037.
• Vincent JP, Mazella J, Kitabgi P (Jul 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
• Vita N, Laurent P, Lefort S, Chalon P, Dumont X, Kaghad M, Gully D, Le Fur G, Ferrara P, Caput D (Feb 1993). "Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor". FEBS Letters 317 (1-2): 139–42. doi:10.1016/0014-5793(93)81509-X. PMID 8381365.
• Le F, Groshan K, Zeng XP, Richelson E (Jan 1997). "Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene". The Journal of Biological Chemistry 272 (2): 1315–22. doi:10.1074/jbc.272.2.1315. PMID 8995438.
• Boudin H, Pélaprat D, Rostène W, Pickel VM, Beaudet A (Oct 1998). "Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra". The Journal of Neuroscience 18 (20): 8473–84. PMID 9763490.
• Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (Oct 1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". The Journal of Biological Chemistry 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
• Wang L, Friess H, Zhu Z, Graber H, Zimmermann A, Korc M, Reubi JC, Büchler MW (Feb 2000). "Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease". Clinical Cancer Research 6 (2): 566–71. PMID 10690540.
• Cusack B, Jansen K, McCormick DJ, Chou T, Pang Y, Richelson E (Sep 2000). "A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist". Biochemical Pharmacology 60 (6): 793–801. doi:10.1016/S0006-2952(00)00409-3. PMID 10930533.
• Oakley RH, Laporte SA, Holt JA, Barak LS, Caron MG (Jun 2001). "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*". The Journal of Biological Chemistry 276 (22): 19452–60. doi:10.1074/jbc.M101450200. PMID 11279203.
• Leplatois P, Josse A, Guillemot M, Febvre M, Vita N, Ferrara P, Loison G (Sep 2001). "Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor". European Journal of Biochemistry / FEBS 268 (18): 4860–7. doi:10.1046/j.0014-2956.2001.02407.x. PMID 11559354.
• Lundquist JT, Büllesbach EE, Golden PL, Dix TA (Feb 2002). "Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs". The Journal of Peptide Research 59 (2): 55–61. doi:10.1046/j.1397-002x.2001.10946.x. PMID 11906607.
• Somaï S, Gompel A, Rostène W, Forgez P (Jul 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
• Martin S, Navarro V, Vincent JP, Mazella J (Oct 2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line". Gastroenterology 123 (4): 1135–43. doi:10.1053/gast.2002.36000. PMID 12360476.
• Toy-Miou-Leong M, Cortes CL, Beaudet A, Rostène W, Forgez P (Mar 2004). "Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation". The Journal of Biological Chemistry 279 (13): 12636–46. doi:10.1074/jbc.M303384200. PMID 14699144.
• Magazin M, Poszepczynska-Guigné E, Bagot M, Boumsell L, Pruvost C, Chalon P, Culouscou JM, Ferrara P, Bensussan A (Jan 2004). "Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor". The Journal of Investigative Dermatology 122 (1): 111–8. doi:10.1046/j.0022-202X.2003.22131.x. PMID 14962098.
• Brun P, Mastrotto C, Beggiao E, Stefani A, Barzon L, Sturniolo GC, Palù G, Castagliuolo I (Apr 2005). "Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation". American Journal of Physiology. Gastrointestinal and Liver Physiology 288 (4): G621–9. doi:10.1152/ajpgi.00140.2004. PMID 15764810.

External links

• "Neurotensin Receptors: NTS₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.