Sermorelin
Systematic (IUPAC) name | |
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L-Tyrosyl-L-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide | |
Clinical data | |
Trade names | Geref |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Pregnancy category |
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Legal status |
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Routes of administration | Injection |
Identifiers | |
CAS Number |
86168-78-7 ![]() |
ATC code | H01AC04 V04CD03 |
PubChem | CID 16132413 |
DrugBank |
DB00010 ![]() |
ChemSpider |
17289071 ![]() |
UNII |
89243S03TE ![]() |
KEGG |
D08509 ![]() |
ChEMBL |
CHEMBL1201490 ![]() |
Synonyms | GRF 1–29 |
Chemical data | |
Formula | C149H246N44O42S |
Molar mass | 3357.882 g/mol |
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Sermorelin (INN) (trade name is Geref), also known as GHRH (1-29), is a growth hormone-releasing hormone (GHRH) analogue used as a diagnostic agent. It is a 29-amino acid polypeptide representing the 1–29 fragment from endogenous human GHRH, and is thought to be the shortest fully functional fragment of GHRH.[1] It is used as a diagnostic agent to assess growth hormone (GH) secretion.[2] It is also used as doping agent in sports due to its correlation with increased growth of muscular and skeletal tissue. Sermorelin use is also hypothesized to improve deep rapid eye movement sleep.
See also
References
- ↑ Prakash A, Goa KL (August 1999). "Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency". BioDrugs 12 (2): 139–57. doi:10.2165/00063030-199912020-00007. PMID 18031173.
- ↑ Pharmacology (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003).
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