Neurotensin receptor 2

Neurotensin receptor 2
Identifiers
Symbols	NTSR2 ; NTR2
External IDs	OMIM: 605538 MGI: 108018 HomoloGene: 7452 IUPHAR: 310 ChEMBL: 2514 GeneCards: NTSR2 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • G-protein coupled neurotensin receptor activity Cellular component • plasma membrane • integral component of plasma membrane Biological process • cell surface receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • sensory perception • regulation of membrane potential Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23620	18217
Ensembl	ENSG00000169006	ENSMUSG00000020591
UniProt	O95665	P70310
RefSeq (mRNA)	NM_012344	NM_008747
RefSeq (protein)	NP_036476	NP_032773
Location (UCSC)	Chr 2: 11.66 – 11.67 Mb	Chr 12: 16.65 – 16.66 Mb
PubMed search

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.^[1][2][3]

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.^[3]

See also

• Neurotensin receptor

References

1. Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (May 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Letters 386 (2-3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296.
2. Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Nov 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". European Journal of Pharmacology 360 (2-3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.
3. "Entrez Gene: NTSR2 neurotensin receptor 2".

Further reading

• Vincent JP, Mazella J, Kitabgi P (Jul 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
• Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP (Sep 1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience 16 (18): 5613–20. PMID 8795617.
• Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, Caput D, Ferrara P, Bensussan A (Sep 2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
• Martin S, Vincent JP, Mazella J (Jan 2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science 115 (Pt 1): 165–73. PMID 11801734.
• Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, Rostène W, Borderie V, Laroche L (Jun 2002). "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science 43 (6): 1765–71. PMID 12036977.
• Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
• Somaï S, Gompel A, Rostène W, Forgez P (Jul 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
• Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (Dec 2004). "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

• "Neurotensin Receptors: NTS₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.