Pancreatic polypeptide receptor 1

Neuropeptide Y receptor Y4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2IK5​
Identifiers
Symbols	NPY4R ; NPY4-R; PP1; PPYR1; Y4
External IDs	OMIM: 601790 MGI: 105374 HomoloGene: 116086 IUPHAR: 307 ChEMBL: 4877 GeneCards: NPY4R Gene
Gene ontology Molecular function • peptide YY receptor activity • pancreatic polypeptide receptor activity • G-protein coupled receptor activity • peptide binding Cellular component • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • digestion • feeding behavior • blood circulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5540	19065
Ensembl	ENSG00000204174	ENSMUSG00000048337
UniProt	P50391	Q61041
RefSeq (mRNA)	NM_001278794	NM_008919
RefSeq (protein)	NP_001265723	NP_032945
Location (UCSC)	Chr 10: 46.46 – 46.47 Mb	Chr 14: 34.14 – 34.15 Mb
PubMed search

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.^[1][2]

Selective Ligands

Agonists

• Pancreatic polypeptide
• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Antagonists

• UR-AK49 ^[3]

See also

• Neuropeptide Y receptor

References

1. Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
2. "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
3. Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.

External links

• "Neuropeptide Y Receptors: Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Keire DA, Bowers CW, Solomon TE, Reeve JR (Feb 2002). "Structure and receptor binding of PYY analogs". Peptides 23 (2): 305–21. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645.
• Balasubramaniam A (Apr 2002). "Clinical potentials of neuropeptide Y family of hormones". American Journal of Surgery 183 (4): 430–4. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.
• Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
• Benaim G, Villalobo A (Aug 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry / FEBS 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
• Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D (Dec 1995). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY". The Journal of Biological Chemistry 270 (49): 29123–8. doi:10.1074/jbc.270.49.29123. PMID 7493937.
• Bard JA, Walker MW, Branchek TA, Weinshank RL (Nov 1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY". The Journal of Biological Chemistry 270 (45): 26762–5. doi:10.1074/jbc.270.45.26762. PMID 7592911.
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
• Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.
• Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H (Dec 1997). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14". Genomics 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761.
• Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.
• Smith FD, Oxford GS, Milgram SL (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". The Journal of Biological Chemistry 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.
• Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164.
• Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Molecular and Cellular Biology 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMC 99861. PMID 11564868.
• Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E (Dec 2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells". The Journal of Clinical Endocrinology and Metabolism 86 (12): 5956–63. doi:10.1210/jc.86.12.5956. PMID 11739470.
• Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
• Wu DY, Tkachuck DC, Roberson RS, Schubach WH (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". The Journal of Biological Chemistry 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.