Phenylethylidenehydrazine

Phenylethylidenehydrazine

Systematic (IUPAC) name
(1E)-(2-Phenylethylidene)hydrazine
Clinical data
Legal status	Uncontrolled
Pharmacokinetic data
Biological half-life	~12 hours
Identifiers
CAS Number	29443-41-2
ATC code	None
PubChem	CID 10103216
ChemSpider	8278744
Chemical data
Formula	C8H10N2
Molar mass	134.18 g/mol
SMILES N/N=C/CC1=CC=CC=C1

Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is an inhibitor of the enzyme GABA transaminase (GABA-T).^[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.^[1] PEH may contribute to phenelzine's anxiolytic effects.

See also

• Phenelzine

References

1. Parent MB, Master S, Kashlub S, Baker GB (January 2002). "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum". Biochemical Pharmacology 63 (1): 57–64. doi:10.1016/S0006-2952(01)00856-5. PMID 11754874.
2. Duffy S, Nguyen PV, Baker GB (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience 126 (2): 423–32. doi:10.1016/j.neuroscience.2004.03.007. PMID 15207360.