ABCC1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1
PDB rendering based on 2cbz.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CBZ​, 4C3Z​
Identifiers
Symbols	ABCC1 ; ABC29; ABCC; GS-X; MRP; MRP1
External IDs	OMIM: 158343 MGI: 102676 HomoloGene: 133779 ChEMBL: 3004 GeneCards: ABCC1 Gene
Gene ontology Molecular function • transporter activity • ATP binding • ATPase activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • plasma membrane • integral component of plasma membrane • membrane • basolateral plasma membrane • extracellular exosome Biological process • leukotriene metabolic process • vitamin metabolic process • water-soluble vitamin metabolic process • transport • cobalamin metabolic process • arachidonic acid metabolic process • response to drug • small molecule metabolic process • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4363	17250
Ensembl	ENSG00000103222	ENSMUSG00000023088
UniProt	P33527	O35379
RefSeq (mRNA)	NM_004996	NM_008576
RefSeq (protein)	NP_004987	NP_032602
Location (UCSC)	Chr 16: 15.95 – 16.14 Mb	Chr 16: 14.36 – 14.48 Mb
PubMed search

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 Predator gene.^[1][2]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.^[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Irinotecan Pathway edit

1. The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

See also

• ATP-binding cassette transporter

References

1. Cole SP, Deeley RG (Jun 1993). "Multidrug resistance-associated protein: sequence correction". Science 260 (5110): 879. doi:10.1126/science.8098549. PMID 8098549.
2. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (Jan 1993). "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line". Science 258 (5088): 1650–4. doi:10.1126/science.1360704. PMID 1360704.
3. "Entrez Gene: ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1".

Further reading

• Lautier D, Canitrot Y, Deeley RG, Cole SP (1996). "Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.". Biochem. Pharmacol. 52 (7): 967–77. doi:10.1016/0006-2952(96)00450-9. PMID 8831715.
• Deeley RG, Cole SP (1998). "Function, evolution and structure of multidrug resistance protein (MRP).". Semin. Cancer Biol. 8 (3): 193–204. doi:10.1006/scbi.1997.0070. PMID 9441948.
• Hegedus T, Orfi L, Seprodi A; et al. (2002). "Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.". Biochim. Biophys. Acta 1587 (2–3): 318–25. doi:10.1016/s0925-4439(02)00095-9. PMID 12084474.
• Chang XB (2007). "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1". Cancer Metastasis Rev. 26 (1): 15–37. doi:10.1007/s10555-007-9041-7. PMID 17295059.
• Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, Scheper RJ, Breimer DD, Borst P (2000). "Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier". J. Clin. Invest. 105 (3): 279–85. doi:10.1172/JCI8267. PMC 377447. PMID 10675353.

External links

• ABCC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.