ABCC13
| ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ABCC13 ; C21orf73; PRED6 | ||||||||||||
| External IDs | OMIM: 608835 GeneCards: ABCC13 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 150000 | n/a | |||||||||||
| Ensembl | ENSG00000243064 | n/a | |||||||||||
| UniProt | Q9NSE7 | n/a | |||||||||||
| RefSeq (mRNA) | NM_138726 | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) |
Chr 21: 14.24 – 14.36 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Putative ATP-binding cassette transporter sub-family C member 13 is a protein that in humans is encoded by the ABCC13 gene.[1]
Function
This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.[1]
See also
- ATP-binding cassette transporter
- ABCC13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
References
Further reading
- Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
- Annilo T, Dean M (Jul 2004). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339.
- Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816.
- Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
- Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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