ABCC13

ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene
Identifiers
Symbols ABCC13 ; C21orf73; PRED6
External IDs OMIM: 608835 GeneCards: ABCC13 Gene
Orthologs
Species Human Mouse
Entrez 150000 n/a
Ensembl ENSG00000243064 n/a
UniProt Q9NSE7 n/a
RefSeq (mRNA) NM_138726 n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr 21:
14.24 – 14.36 Mb		 n/a
PubMed search n/a

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that in humans is encoded by the ABCC13 gene.[1]

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.[1]

See also

References

  1. 1 2 "Entrez Gene: ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13".

Further reading

  • Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856. 
  • Annilo T, Dean M (Jul 2004). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258. 
  • Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339. 
  • Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816. 
  • Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298. 
  • Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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