ACOT12

Acyl-CoA thioesterase 12
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3B7K​, 4MOB​, 4MOC​
Identifiers
Symbols	ACOT12 ; CACH-1; Cach; STARD15; THEAL
External IDs	OMIM: 614315 MGI: 1921406 HomoloGene: 12540 GeneCards: ACOT12 Gene
EC number	3.1.2.1
Gene ontology Molecular function • acetyl-CoA hydrolase activity • ATP binding • lipid binding • carboxylic ester hydrolase activity Cellular component • cytosol Biological process • acetyl-CoA metabolic process • pyruvate metabolic process • fatty acid metabolic process • acyl-CoA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	134526	74156
Ensembl	ENSG00000172497	ENSMUSG00000021620
UniProt	Q8WYK0	Q9DBK0
RefSeq (mRNA)	NM_130767	NM_028790
RefSeq (protein)	NP_570123	NP_083066
Location (UCSC)	Chr 5: 81.33 – 81.39 Mb	Chr 13: 91.74 – 91.79 Mb
PubMed search

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene.^[1][2][3] The protein contains a StAR-related lipid transfer domain.

References

1. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
2. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157.
3. "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".

Further reading

• Suematsu N, Isohashi F (2007). "Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase.". Acta Biochim. Pol. 53 (3): 553–61. PMID 16951743.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suematsu N, Okamoto K, Isohashi F (2004). "Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase.". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 790 (1-2): 239–44. doi:10.1016/s1570-0232(03)00167-3. PMID 12767336.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suematsu N, Okamoto K, Shibata K; et al. (2001). "Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase.". Eur. J. Biochem. 268 (9): 2700–9. doi:10.1046/j.1432-1327.2001.02162.x. PMID 11322891.