Acyl-CoA hydrolase

acyl-CoA hydrolase
Identifiers
EC number	3.1.2.20
CAS number	37270-64-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an acyl-CoA hydrolase (EC 3.1.2.20) is an enzyme that catalyzes the chemical reaction

acyl-CoA + H₂O $\rightleftharpoons$ CoA + a carboxylate

Thus, the two substrates of this enzyme are acyl-CoA and H₂O, whereas its two products are CoA and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y7U and 2GVH.

References

• Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat". Biochim. Biophys. Acta 1005 (1): 13–9. doi:10.1016/0005-2760(89)90025-8. PMID 2570608.