ALPI

Alkaline phosphatase, intestinal
Identifiers
Symbols	ALPI ; IAP
External IDs	OMIM: 171740 MGI: 1924018 HomoloGene: 134333 ChEMBL: 5573 GeneCards: ALPI Gene
EC number	3.1.3.1
Gene ontology Molecular function • magnesium ion binding • protease binding • alkaline phosphatase activity • protein binding • zinc ion binding Cellular component • plasma membrane • integral component of membrane • anchored component of membrane Biological process • protein dephosphorylation • dephosphorylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	248	11648
Ensembl	ENSG00000163295	ENSMUSG00000036500
UniProt	P09923	Q0VD75
RefSeq (mRNA)	NM_001631	NM_007432
RefSeq (protein)	NP_001622	NP_031458
Location (UCSC)	Chr 2: 232.46 – 232.46 Mb	Chr 1: 87.12 – 87.13 Mb
PubMed search

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.^[1][2]

References

1. Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 695–8. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.
2. Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proc. Natl. Acad. Sci. U.S.A. 84 (5): 1234–8. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.

Further reading

• Hirasaka K, Tokuoka K, Nakao R; et al. (2008). "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells.". J Physiol Sci 58 (2): 105–11. doi:10.2170/physiolsci.RP013007. PMID 18307834.
• Mahmood A, Shao JS, Alpers DH (2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G433–41. doi:10.1152/ajpgi.00466.2002. PMID 12660142.
• Wada A, Wang AP, Isomoto H; et al. (2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.". Int. J. Med. Microbiol. 294 (7): 427–35. doi:10.1016/j.ijmm.2004.09.012. PMID 15715171.
• Nakano T, Inoue I, Alpers DH; et al. (2009). "Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G207–14. doi:10.1152/ajpgi.90590.2008. PMID 19407215.
• Malo MS, Zhang W, Alkhoury F; et al. (2004). "Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element.". Mol. Endocrinol. 18 (8): 1941–62. doi:10.1210/me.2003-0351. PMID 15143152.
• Rump A, Kasper G, Hayes C; et al. (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1.". Genomics 73 (1): 50–5. doi:10.1006/geno.2000.6504. PMID 11352565.
• Nauli AM, Zheng S, Yang Q; et al. (2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation.". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (4): G583–7. doi:10.1152/ajpgi.00482.2002. PMID 12466148.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Alkhoury F, Malo MS, Mozumder M; et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
• Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.". Semin. Oncol. 29 (6 Suppl 19): 14–21. doi:10.1053/sonc.2002.37356. PMID 12577238.
• Torres MI, Lorite P, López-Casado MA, RÃos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.". Pathol. Res. Pract. 203 (6): 485–7. doi:10.1016/j.prp.2007.02.003. PMID 17498884.
• Hinnebusch BF, Siddique A, Henderson JW; et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23–30. doi:10.1152/ajpgi.00203.2003. PMID 12919939.
• Le Du MH, Millan JL (2002). "Structural evidence of functional divergence in human alkaline phosphatases.". J. Biol. Chem. 277 (51): 49808–14. doi:10.1074/jbc.M207394200. PMID 12372831.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldberg RF, Austen WG, Zhang X; et al. (2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3551–6. doi:10.1073/pnas.0712140105. PMC 2265168. PMID 18292227.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen L, Bressendorff S, Troelsen JT, Olsen J (2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G220–6. doi:10.1152/ajpgi.00449.2004. PMID 15831710.
• Fumoto K, Hoogenraad CC, Kikuchi A (2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.". EMBO J. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.