Inositol monophosphatase 2

Inositol(myo)-1(or 4)-monophosphatase 2
PDB rendering based on 2czh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CZH​, 2CZI​, 2CZK​, 2DDK​, 2FVZ​
Identifiers
Symbol	IMPA2
External IDs	OMIM: 605922 MGI: 2149728 HomoloGene: 22799 ChEMBL: 1776 GeneCards: IMPA2 Gene
EC number	3.1.3.25
Gene ontology Molecular function • magnesium ion binding • protein binding • inositol monophosphate 1-phosphatase activity • protein homodimerization activity • inositol monophosphate 3-phosphatase activity • inositol monophosphate 4-phosphatase activity Cellular component • cytoplasm • cytosol Biological process • inositol metabolic process • inositol biosynthetic process • protein dephosphorylation • phosphate-containing compound metabolic process • signal transduction • inositol phosphate metabolic process • small molecule metabolic process • phosphatidylinositol phosphorylation • inositol phosphate dephosphorylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3613	114663
Ensembl	ENSG00000141401	ENSMUSG00000024525
UniProt	O14732	Q91UZ5
RefSeq (mRNA)	NM_014214	NM_053261
RefSeq (protein)	NP_055029	NP_444491
Location (UCSC)	Chr 18: 11.98 – 12.03 Mb	Chr 18: 67.29 – 67.32 Mb
PubMed search

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.^[1][2] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.^[3]

References

1. Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233.
2. "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".
3. Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Yoshikawa T, Padigaru M, Karkera JD, et al. (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID 10822344.
• Sjøholt G, Gulbrandsen AK, Løvlie R, et al. (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID 10822345.
• Yoon IS, Li PP, Siu KP, et al. (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID 11673796.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA 9 (12): 1532–41. doi:10.1261/rna.5143303. PMC 1370506. PMID 14624008.
• Sjøholt G, Ebstein RP, Lie RT, et al. (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID 14699425.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nakayama J, Yamamoto N, Hamano K, et al. (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID 15557493.
• Ohnishi T, Ohba H, Seo KC, et al. (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.
• Ohnishi T, Yamada K, Ohba H, et al. (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology 32 (8): 1727–37. doi:10.1038/sj.npp.1301307. PMID 17251911.
• Arai R, Ito K, Ohnishi T, et al. (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins 67 (3): 732–42. doi:10.1002/prot.21299. PMID 17340635.
• Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID 17388992.