Inositol monophosphatase 3

Inositol monophosphatase domain containing 1

Identifiers

IMPAD1 ; GPAPP; IMP 3; IMP-3; IMPA3

External IDs

OMIM: 614010 HomoloGene: 9852 GeneCards: IMPAD1 Gene

Gene ontology
Molecular function	• magnesium ion binding • 3'-nucleotidase activity • 3'(2'),5'-bisphosphate nucleotidase activity • inositol monophosphate 1-phosphatase activity • inositol monophosphate 3-phosphatase activity • inositol monophosphate 4-phosphatase activity
Cellular component	• Golgi apparatus • membrane • integral component of membrane
Biological process	• endochondral ossification • chondrocyte development • inositol biosynthetic process • protein dephosphorylation • post-embryonic development • dephosphorylation • chondroitin sulfate metabolic process • embryonic digit morphogenesis • phosphatidylinositol phosphorylation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
56.96 – 56.99 Mb

Chr 4:
4.76 – 4.79 Mb

PubMed search

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.^[1]

This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP).^[1]

Clinical significance

Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1.^[1]

References

1 2 3 "Entrez Gene: Inositol monophosphatase domain containing 1".

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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