Formyl-CoA hydrolase

formyl-CoA hydrolase
Identifiers
EC number	3.1.2.10
CAS number	9025-91-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a formyl-CoA hydrolase (EC 3.1.2.10) is an enzyme that catalyzes the chemical reaction

formyl-CoA + H₂O $\rightleftharpoons$ CoA + formate

Thus, the two substrates of this enzyme are formyl-CoA and H₂O, whereas its two products are CoA and formate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is formyl-CoA hydrolase. This enzyme is also called formyl coenzyme A hydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

• Sly WS and Stadtman ER (1963). "Formate metabolism. I. Formyl coenzyme A, an intermediate in the formate-dependent decomposition of acetyl phosphate in Clostridium kluyveri". J. Biol. Chem. 238: 2632–2638.