Acetyl-CoA hydrolase

acetyl-CoA hydrolase
Identifiers
EC number 3.1.2.1
CAS number 9027-54-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an acetyl-CoA hydrolase (EC 3.1.2.1) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H2O \rightleftharpoons CoA + acetate + H+

Thus, the two substrates of this enzyme are acetyl-CoA and H2O, whereas its two products are CoA and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acetyl-CoA hydrolase. Other names in common use include acetyl-CoA deacylase, acetyl-CoA acylase, acetyl coenzyme A hydrolase, acetyl coenzyme A deacylase, acetyl coenzyme A acylase, and acetyl-CoA thiol esterase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H4U.

References

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