ACSS3

acyl-CoA synthetase short-chain family member 3

Identifiers

External IDs

MGI: MGI:2685720 HomoloGene: 11587 GeneCards: 79611

Gene ontology
Molecular function	• acetate-CoA ligase activity • nucleotide binding • ligase activity • catalytic activity • ATP binding
Cellular component	• mitochondrion
Biological process	• metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


Q9H6R3 H0YII9


Q14DH7

RefSeq (mRNA)


XR_944720 NM_024560 XM_005269150 XM_005269151 XM_011538740


NM_001142804 NM_198636

RefSeq (protein)


NP_078836.1 XP_011537042.1


NP_001136276.1 NP_941038.2

Location (UCSC)

Chr 12: 80.94 – 81.26 Mb

Chr 10: 106.94 – 107.12 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.^[1]

Function

ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.^[2]

References

↑ "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".
↑ Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP (Sep 2013). "A genome-wide association study of a sustained pattern of antidepressant response". Journal of Psychiatric Research 47 (9): 1157–65. doi:10.1016/j.jpsychires.2013.05.002. PMC 3710535. PMID 23726668.
Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Enzymes: CO CS and CN ligases (EC 6.1-6.3)

6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase

6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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ACSS3

Function

References

Further Reading