APIP

APAF1 interacting protein
X-ray structure of APIP. PDB entry 4m6r​[1]
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4M6R​
Identifiers
Symbols	APIP ; APIP2; CGI-29; CGI29; MMRP19; hAPIP
External IDs	OMIM: 612491 MGI: 1926788 HomoloGene: 6277 GeneCards: APIP Gene
EC number	4.2.1.109
Gene ontology Molecular function • protein binding • zinc ion binding • identical protein binding • methylthioribulose 1-phosphate dehydratase activity Cellular component • cytoplasm Biological process • sulfur amino acid metabolic process • polyamine metabolic process • apoptotic process • L-methionine biosynthetic process from S-adenosylmethionine • L-methionine biosynthetic process from methylthioadenosine • cellular nitrogen compound metabolic process • negative regulation of apoptotic process • small molecule metabolic process • regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51074	56369
Ensembl	ENSG00000149089	ENSMUSG00000010911
UniProt	Q96GX9	Q9WVQ5
RefSeq (mRNA)	NM_015957	NM_019735
RefSeq (protein)	NP_057041	NP_062709
Location (UCSC)	Chr 11: 34.85 – 34.92 Mb	Chr 2: 103.07 – 103.09 Mb
PubMed search

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.^[2][3][4] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity^[5][1] which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death^[6] and cancer.

Interactions

APIP has been shown to interact with APAF1.^[3]

References

1. Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C.; Kim, T. Y.; Ashida, H; Yokota, A; Hah, S. S.; Chun, K. H.; Jung, Y. K.; Yang, J. K. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences 111 (1): E54–61. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
2. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
3. Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.
4. "Entrez Gene: APIP APAF1 interacting protein".
5. Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F, ed. "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLoS ONE 7 (12): e52877. doi:10.1371/journal.pone.0052877. PMC 3532061. PMID 23285211.
6. Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171. PMID 22837397.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.