Methylthioribulose 1-phosphate dehydratase

methylthioribulose 1-phosphate dehydratase

X-ray structure of human methylthioribulose 1-phosphate dehydratase (APIP). PDB entry 4m6r[1]
Identifiers
EC number 4.2.1.109
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a methylthioribulose 1-phosphate dehydratase (EC 4.2.1.109) is an enzyme that catalyzes the chemical reaction

S-methyl-5-thio-D-ribulose 1-phosphate \rightleftharpoons 5-(methylthio)-2,3-dioxopentyl phosphate + H2O

Hence, this enzyme has one substrate, S-methyl-5-thio-D-ribulose 1-phosphate, and two products, 5-(methylthio)-2,3-dioxopentyl phosphate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]. Other names in common use include 1-PMT-ribulose dehydratase, and S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase. This enzyme participates in methionine metabolism.

References

  1. Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C.; Kim, T. Y.; Ashida, H; Yokota, A; Hah, S. S.; Chun, K. H.; Jung, Y. K.; Yang, J. K. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences 111 (1): E54–61. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
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