3-Isopropylmalate dehydratase

3-Isopropylmalate dehydratase (E.C.4.2.1.33) is an aconitase homologue,^[1]^[2]^[3] which catalyses the isomerisation of 2-isopropylmalate to 3-isopropylmalate, via dehydration, in the biosynthesis of leucine.

References

↑ Gross SR, Burns RO, Umbarger HE (1963). "The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate". Biochemistry 2 (5): 1046–52. doi:10.1021/bi00905a023. PMID 14087357.
↑ Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE (December 1964). "The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis". Biochemistry 3 (12): 2024–7. doi:10.1021/bi00900a043. PMID 14269331.
↑ Cole FE, Kalyanpur MG, Stevens CM (August 1973). "Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine". Biochemistry 12 (17): 3346–50. doi:10.1021/bi00741a031. PMID 4270046.

External links

3-isopropylmalate dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

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