APOBEC2

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
PDB rendering based on 2nyt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NYT​
Identifiers
Symbols	APOBEC2 ; ARCD1; ARP1
External IDs	OMIM: 604797 MGI: 1343178 HomoloGene: 4941 GeneCards: APOBEC2 Gene
EC number	3.5.4.-
Gene ontology Molecular function • RNA binding • cytidine deaminase activity • zinc ion binding Biological process • mRNA processing • cytidine deamination • mRNA modification • DNA demethylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10930	11811
Ensembl	ENSG00000124701	ENSMUSG00000040694
UniProt	Q9Y235	Q9WV35
RefSeq (mRNA)	NM_006789	NM_009694
RefSeq (protein)	NP_006780	NP_033824
Location (UCSC)	Chr 6: 41.05 – 41.06 Mb	Chr 17: 48.42 – 48.43 Mb
PubMed search

Probable C->U-editing enzyme APOBEC-2 is a protein that in humans is encoded by the APOBEC2 gene.^[1][2]

References

1. Liao W, Hong SH, Chan BH, Rudolph FB, Clark SC, Chan L (Aug 1999). "APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family". Biochem Biophys Res Commun 260 (2): 398–404. doi:10.1006/bbrc.1999.0925. PMID 10403781.
2. "Entrez Gene: APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2".

Further reading

• Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
• Lau PP, Zhu HJ, Baldini A; et al. (1994). "Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8522–6. doi:10.1073/pnas.91.18.8522. PMC 44638. PMID 8078915.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Oka K, Kobayashi K, Sullivan M; et al. (1997). "Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice". J. Biol. Chem. 272 (3): 1456–60. doi:10.1074/jbc.272.3.1456. PMID 8999814.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Anant S, Mukhopadhyay D, Sankaranand V; et al. (2001). "ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing". Am. J. Physiol., Cell Physiol. 281 (6): C1904–16. PMID 11698249.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Prochnow C, Bransteitter R, Klein MG; et al. (2007). "The APOBEC-2 crystal structure and functional implications for the deaminase AID". Nature 445 (7126): 447–51. doi:10.1038/nature05492. PMID 17187054.